Marcello Cherchi’s embryology notes
2DAY 6:Blastocyst has implanted itself on the endometrial surface of the uterus (SA 36) andtrophoblast cells begin to penetrate the uterine epithelium (SA 35).DAY 8: (SA 41-2)Blastocyst is partially embedded in the endometrial stroma (SA 41).
forms in the epiblast.Inner cell mass has differentiated into two layers which constitute the
Trophoblast has differentiated into:1)
= outer, multinucleated zone at the juncture between theblastocyst and the endometrial stroma.2)
= inner layer of mononucleated cells.Blastocyst cavityDAY 9: (SA 43)The blastocyst is almost entirely embedded in the uterine lining, and a
(orfibrin coagulum) fills in the remaining gap.Trophoblastic
appear. Enlarged blood vessels appear in the endometrial lining.The blastocyst cavity is now called the
primitive yolk sac
(or exocoelomic cavity). Itsinner side is lined by the
exocoelomic (Heuser’s) membrane
.DAY 12: (SA 44)The primitive yolk sac is now known as the
line the inside of the primitive yolk sac in the hemisphere towards theuterus.
develops between the trophoblast externally and the amnionand exocoelomic membrane internally.Large cavities develop in the extraembryonic endoderm and when they become confluent,they form a space called the
.The trophoblastic lacunae enlarge. The enlarging blood vessels become
which establish the
DAY 13: (SA 45-7)The hypoblast produces additional cells that migrate along the inside of the exocoelomicmembrane. These cells proliferate and gradually form a new cavity within theexocoelomic cavity. This new cavity is called the
secondary yolk sac
, which is much smaller than the original exocoelomic cavity or primitive yolk sac(see SA 46).