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Prednisolone

Prednisolone

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Published by Katie McPeek

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Published by: Katie McPeek on Oct 17, 2008
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09/25/2013

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NURS 1566 Clinical Form 3: Clinical Medications Worksheets
(You will need to make additional copies of these forms)Generic NamePrednisoloneTrade Name NorpredClassificationAntiasthmatics,corticosteroidsDose50 mgRouteIVTime/frequencyQ DayPeak 1 hr OnsetRapidDurationUnknown Normal dosage range4-60 mg/dayWhy is your patient getting this medicationUsed systemically and locally in a wide variet of chronicdiseases including: Inflammatory, allergic, hematologic,neoplastic, autoimmune disorders, asthma.For IV meds, compatibility with IV drips and/or solutionsDo not use the acetate form of this drug for IVadministration. May be added to D5W or 0.9% NaCl
RATE:
No more than 10 mg/minMechanism of action and indications(Why med ordered)In pharmacologic doses, all agents suppressinflammation and the normal immune response. Allagents have numerous intense metabolic effects.Suppress adrenal function at chronic doses of rednisolone5 mg/day. Prednisolone have minimal mineralocorticoidactivity. Suppression of inflammation and modificationof the normal immune response. Replacement therapy inadrenal insufficiency.
Nursing Implications (what to focus on)
 Contraindicated in active untreated infections. Knownalcohol, bisulfite, or tartrazine hypersensitivity or intolerance. Use cautiously in chronic treatment; Stress;supplemental doses may be needed.Common side effectsMuch more common with high-dose long term therapy— CNS: Depression, euphoria, headache, personality changes, psychoses, restlessness. EENT: Cataracts, increasedintraocular pressure. CV: hypertension. GI: Peptic ulceration,anorexia, nausea, vomiting. DERM: acne, decreased woundhealing, ecchymosis, fragility, hirsutism, petechiae. ENDO:adrenal suppression, hyperglycemia. F and E: fluid retention,hypokalemia, hypokalemic alkalosis. HEMAT:Thromboembolism, thrombophlebitis. METAB: Weight gain.MS: muscle wasting, osteoporosis, aseptic necrosis of joints,muscle pain. MISC: cushingoid appearance (moon face, buffalo hump), increased susceptibility to infection.Interactions with other patient drugs, OTC or herbalmedicines (ask patient specifically)At chronic doses that suppress adrenal function, maydecrease antibody response to and increase risk of adverse reactions from live virus vaccines. May decreasesalicylate levels and effectiveness.Lab value alterations caused by medicineMonitor serum electrolytes and glucose, may causehyperglycemia. Routine hematologic values, serumelectrolytes, and serum and urine glucose with long termtreatment. May decrease WBCs. May decrease serum potassium and calcium and increase serum sodiumconcentrations. May increase serum cholesterol and lipidvalues. May decrease the uptake of thyroid. Periodic adenalfunction tests should be orderedBe sure to teach the patient the following about thismedicationTake as directed. Take missed doses as soon as rememberedunless almost time for the next dose. Do not abruptly stopmedication. Watch for signs of adrenal insufficiency.

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