Professional Documents
Culture Documents
Public Health
Michael R. Gray, MD, MPH, CIME
Internal and Occupational Medicine
Emergency Medicine & Toxicology
In collaboration with
Kaye Kilburn, MD
Internal Medicine and Neurotoxicology
Robert Crago, Ph.D.
Psychology, Neurophysiology and
Neurotherapy
ImmunTox, LLC
PO Box 2050 Benson, Arizona 85602
Ras h
Coordin
ation pro
b lems
Ins omnia
J oint Dis
c omfort
Lighthea
de d
Means
Throat d
is co mfor
t
Wa tery E
es y
Coughin
g
Spa cine
ss
Mem ory
Problem
s
Nas al S
ympto ms
Headac h
e
156 Exposed Patient’s Compared to 28 Referent Patient’s
Fatigu e
Exposed
Compared Symptom Profiles
Non Exposed
11
Historical Perspective
• Spring 1998
– CDC MMWR 9 cases
hemorrhagic pneumonitis in Infants
• Stachybotrys chartarum found in lungs
– Stachybotrys chartarum (atra) present
in homes
– In National Survey Ruth Etzel, MD, Ph.D.
finds 115 cases of hemosiderosis associated
with mold exposure (mortality approx. 15%)
50.000
50.000
45.000
45.000
40.000
40.000
35.000
35.000
30.000 Exposed
Exposed Mean
Mean
30.000
Min Normal
Min Normal
25.000
25.000
Mean
Mean Normal
Normal
20.000
20.000 Max
Max Normal
Normal
15.000
15.000
10.000
10.000
5.000
5.000
0.000
0.000
RR+
RR+
22))
++
lss)
++
+
+
)
388
266
el ll
I LL
D3
D2
Ce
--DD
--DD
++((I
CCD
CCD
BB C
LAA
LAA
255
HHL
HHL
8++
D2
++((
33++
D8
CCD
CD
3++
8++
2200
CCDD
D3
D8
%%C
CD
CD
CCDD
5++
%%C
%%C
5
%%
CDD
%%
C
%%
20.0 45.0
20 45
18 40
16 35
14 12.5
30 25.0
12
25
10 7.7 20
8
5.0 15
6
10 5.0 5.3
4
5
2
0
0
Low Exposed Mean High Low Exposed Mean High
Normal Mean Normal Normal Normal Mean Normal Normal
400
200 300
150
200
100
100
50
0
Low Normal Exposed Mean Normal High Normal
0
Low Nor ma l Expose d Me a n Me a n Nor ma l High Nor ma l
Mean
Autoimmune
Autoimmune Antibodies
Antibodies Patients
Patientsw/
w/Pos
PosAutoantibodies
Autoantibodiesof
of195
195Total
TotalPatients
Patients
120
120 40
40
100
100 Pts 35
35
Pts at
at 256
256
80 Pts at 128 30
30
80 Pts at 128 Pts
25 Pts atat40
40
60
60 Pts
Pts at
at 64
64 25
Pts
Pts atat80
80
40 Pts at 32 20
20
40 Pts at 32 Pts
Pts atat160
160
Pts
Pts at
at 16
16 15
15
20 Pts
20 Pts atat320
320
10
10
00
CNS CNS CNA Periph Periph Periph 55
CNS CNS CNA Periph Periph Periph
Myelin
Myelin Myelin
Myelin Myelin
Myelin Nerve
Nerve Nerve
Nerve Nerve
Nerve 00
IgG IgA IgM IgG IgA IgM Anti-nuclear
IgG IgA IgM IgG IgA IgM Anti-nuclearAb
Ab Anti-Smooth
Anti-SmoothAb
Ab
80
70
60
50
40
30
20
10
0
Critical Very severe Severe Moderate Mild
Nonsmokers Smokers
80
60
40 Nonsmokers
Smokers
20
0
Pre FEF75% Post FEF75%
70
60
50
40
30
20
10
0
> 20 Years 11 to 20 6 to 10 1 to 5
Headaches
Remembering things
Trouble conc
Worrying
Blank Mind
Double-check
Feeling weak
Feeling tense
Feeling blue
Nervousness
Muscle soreness
Hot/cold spells
Tingling
0 3 6 9 12 15 18 21 24
Reaction Tim e
104
102
100
98
96
Simple Reaction Choice Reaction
Time (ms) Time (ms)
P=0.0001 P=0.0001
200
150
100
50
0
Eyes Opened Eyes Closed
P=0.0001 P=0.0001
120
115
110
105
100 4 3 EXPOSED M EAN
95 2 0 2 REFERENT M EAN
90
85
Right Lef t
P=0.0001 P=0.0001
120
100
80
60 4 3 EXPOSED MEAN
40 2 0 2 R EFERENT MEAN
20
0
Right Left P=0.002
P=0.0001
105
100
95
43 EXPOSED MEAN
90
202 REFERENT MEAN
85
80
Right Left
P=0.006 P=0.008
100
98
96
94
92
90
43 EXP OS ED MEAN
88 202 REFERENT MEAN
86
84
82
80
Right P=0.012 Lef t
P=0.0001
100
90
80
70
60
50 43 EXPOSED MEAN
40 202 REFERENT MEAN
30
20
10
0
Immediate Delayed
P=0.0001 P=0.0001
120
100
80
60
40
20
0
Information Picture Simularities
P=0.052 Completion P=0.691
P=0.0002
• Hypersensitivity
pneumonitis