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Biochem Test 3

Biochem Test 3

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 Pharmaceutical Biochemistry, 341CExam #3,Dr. Dalby,100pts; 30 Single answer questions, (Print legibly)December 5
th
, 2002. NAME ___________ INSTRUCTIONSThere is one single answer for each question.Use the scantron to mark your results.Hand in BOTH this exam sheet and your scantron with your nameon both.ONE SINGLEANSWER 1 Which of the following statements about mitochondria is/are
 false
?a.
 
They contain proteins that participate in glycolysis. b.
 
The region enclosed by the inner membrane is termed thematrix.c.
 
The inner membrane is permeable to most smallmolecules.d.
 
They generate NADH as part of the Krebs cycle.A. a and b are falseB. only b is falseC. only a is falseD. b and c are falseE. a and c are falseA is false because all glycolytic enzymes are found in thecytoplasm. The pyruvate dehydrogenase complex is not part of the glycolytic pathway. C is false because the inner mitochondrialmembrane is impermeable to most small molecules.2 Which of the following statements is/are
 false
?a.
 
In the cytoplasm pyruvate is converted to acetyl CoA b.
 
Aerobic glycolysis produces NADH in the mitochondriac.
 
A transport system takes the pyruvate from the cytoplasmto the inner mitochondrial membrane.d.
 
 NADH cannot enter the mitochondrial matrix from thecytosol.A. a and b are falseB. b and c are falseC. only b is falseD. a and d are falseE. c and d are falsePyruvate is converted to acetyl CoA in the mitochondria by the pyruvate dehydrogenase complex.
 
PDH is a large cluster of three enzymes (E1, E2, E3) in the mitochondrial matrix of eukaryotic cells.
Aerobic glycolysis produces NADH in thecytoplasm. The electrons in NADH are transported into themitochondria by the glycerol phosphate shuttle or the malate-aspartate shuttle, which is found in the kidney, liver and heart.3 Identify the fused ring lipida.
 
Phosphatidylinositol. b.
 
Ceramide.c.
 
A bile acid.d.
 
AMP.A. aB. bC. cD. d
 
e.
 
RNA. E. ea and b are membrane lipids, with long chains. AMP (adenosine monophosphate) and RNA are not lipids.4 Which of the following statements (a-d) is/are
true
?a.
 
Acetyl CoA is a biosynthetic precursor of fatty acids. b.
 
Triacylglycerols contain two carboxylic ester bonds.c.
 
The metabolically active form of a fatty acid (for oxidation) is a thioester.d.
 
 pyrophosphate hydrolysis is thermodynamicallyunfavorable.A. a and c are trueB. a and b are trueC. only c is trueD. only d is trueE. a and d are trueB is false because TAGS contain 3 carboxylic ester bonds not 2. D is false because the hydrolysis of  pyrophosphate is thermodynamically favorable, because pyruvate contains a high energy phosphoanyhdridelinkage5 Which of the following statements is
 false
?a.
 
The oxidative degradation of fatty acids to give acetylCoA generates NADH, but not FADH
2
. b.
 
 Nearly all fatty acids found in plants have an odd number of carbons.c.
 
The oxidation of fatty acids occurs in the mitochondria of a cell.A. a and b are falseB. only b is falseC. only a is falseD. only c is falseE. None are falseA is false because FADH
2
is formed by acyl-CoA dehydrogenase(reaction 1) of beta-oxidation. B is wrong because most are even.6 The final species to be reduced in the electron transport chain isa.
 
O
2
  b.
 
Water c.
 
cytochrome
c
 d.
 
coenzyme Qe.
 
none of the aboveA. aB. bC. cD. dE. eOxygen is reduced by the addition of electrons in the final step to produce water.7The
β
-oxidation of fatty acids is not characterized bya.
 
initiation at the methyl end of the fatty acid b.
 
its role as primary route to degradation of fatty acidsc.
 
taking place in the mitochondrial matrixd.
 
two-carbon units being eliminated at each stepA. aB. bC. cD. dA is false because the fatty acids are activated at the carboy end byreacting with ATP to give RCOO-AMP which the reacts withCoASH to give the acyl-CoA8 Which of the following are major physiologic functions of FREE
 
fatty acids?a.
 
They stabilize the structure of membranes b.
 
They serve as fuel moleculesc.
 
They are precursors of triaclylglycerolsA. a and bB. a and cC. b and cD. only aE. allA is false because free fatty acids do not associate with membranes.The key to this question is to see that we are talking about FREE fatty acids not fatty acids that form part of a phosphodiacyl glycerol

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