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Dùng Thuốc Chữa bệnh GUT

Dùng Thuốc Chữa bệnh GUT

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Published by: api-3833952 on Oct 18, 2008
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05/09/2014

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D\u00f9ng thu\u1ed1c ch\u1eefa b\u1ec7nh GUT (th\u1ed1ng phong)

T\u00f4i b\u1ecb b\u1ec7nh gut, \u0111\u00e3 \u0111i\u1ec1u tr\u1ecb b\u1eb1ng colchicin nhi\u1ec1u l\u1ea7n nh\u01b0ng kh\u00f4ng kh\u1ecfi. C\u00e0ng v\u1ec1 sau c\u00e0ng x\u1ea3y ra d\u00e0y h\u01a1n. Xin \u0111\u1ec1 ngh\u1ecb b\u00e1o ch\u1ec9 d\u1eabn n\u00ean d\u00f9ng thu\u1ed1c g\u00ec v\u00e0 nh\u01b0 th\u1ebf n\u00e0o? L\u01b0\u01a1ng Trung H\u00f2a(Ph\u01b0\u1eddng Thu\u1eadn L\u1ed9c - th\u00e0nh ph\u1ed1 Hu\u1ebf)

C\u1ea7n x\u00e1c \u0111\u1ecbnh c\u00f3 th\u1eadt b\u1ecb b\u1ec7nh gut hay kh\u00f4ng?

Acid uric l\u00e0 s\u1ea3n ph\u1ea9m cu\u1ed1i c\u00f9ng c\u1ee7a qu\u00e1 tr\u00ecnh tho\u00e1i gi\u00e1ng c\u00e1c nucleo-protein. C\u00e1c
nucleo-protein \u0111\u00f3 c\u00f3 th\u1ec3 l\u00e0 t\u1eeb th\u1ee9c \u0103n, t\u1eeb t\u1ebf b\u00e0o ch\u1ebft, t\u1eeb s\u1ef1 t\u1ed5ng h\u1ee3p n\u1ed9i sinh. B\u00ecnh
th\u01b0\u1eddng acid uric \u0111\u01b0\u1ee3c th\u1ea3i tr\u1eeb ra ngo\u00e0i c\u01a1 th\u1ec3 b\u1eb1ng \u0111\u01b0\u1eddng th\u1eadn (n\u01b0\u1edbc ti\u1ec3u), \u0111\u01b0\u1eddng ti\u00eau
h\u00f3a (ph\u00e2n). Khi s\u1ea3n sinh v\u00e0 th\u1ea3i tr\u1eeb acid uric c\u00e2n b\u1eb1ng th\u00ec l\u01b0\u1ee3ng acid uric - m\u00e1u s\u1ebd \u1edf
ng\u01b0\u1ee1ng an to\u00e0n. Khi c\u00e1c ngu\u1ed3n nucleo-protein t\u0103ng nh\u01b0 qu\u00e1 tr\u00ecnh t\u1ed5ng h\u1ee3p n\u1ed9i sinh
t\u0103ng, qu\u00e1 tr\u00ecnh h\u1ee7y ho\u1ea1i t\u1ebf b\u00e0o t\u0103ng (b\u1ec7nh \u00e1c t\u00ednh, b\u1ec7nh tan m\u00e1u hay do d\u00f9ng thu\u1ed1c di\u1ec7t
t\u1ebf b\u00e0o) th\u00ec acid uric sinh ra nhi\u1ec1u. Khi s\u1ef1 th\u1ea3i tr\u1eeb acid uric qua th\u1eadn gi\u1ea3m (do suy th\u1eadn
m\u1ea1n hay do d\u00f9ng thu\u1ed1c l\u1ee3i ti\u1ec3u k\u00e9o d\u00e0i, ng\u1ed9 \u0111\u1ed9c ch\u00ec), ho\u1eb7c khi men HGPR tranferase b\u1ecb
\u1ee9c ch\u1ebf kh\u00f4ng t\u00e1i d\u00f9ng acid uric th\u00ec acid uric c\u0169ng t\u0103ng. B\u1ec7nh gut l\u00e0 b\u1ec7nh r\u1ed1i lo\u1ea1n chuy\u1ec3n
h\u00f3a acid uric trong \u0111\u00f3 acid uric - m\u00e1u t\u0103ng qu\u00e1 cao ng\u01b0\u1ee1ng an to\u00e0n. S\u1ef1 r\u1ed1i lo\u1ea1n chuy\u1ec3n
h\u00f3a \u0111\u00f3 ch\u1ee7 y\u1ebfu do nguy\u00ean nh\u00e2n n\u1ed9i sinh nh\u01b0ng ch\u1ebf \u0111\u1ed9 \u0103n u\u1ed1ng l\u00e0m t\u0103ng ngu\u1ed3n nucleo-
protein c\u0169ng g\u00f3p ph\u1ea7n quan tr\u1ecdng. Bi\u1ec3u hi\u1ec7n: c\u00f3 nh\u1eefng c\u01a1n vi\u00eam v\u00e0 \u0111au kh\u1edbp c\u1ea5p,
th\u01b0\u1eddng khu tr\u00fa \u1edf ng\u00f3n ch\u00e2n c\u00e1i v\u00e0 c\u00e1c kh\u1edbp ng\u00f3n b\u00e0n ch\u00e2n, l\u1eafng \u0111\u1ecdng mu\u1ed1i c\u1ee7a acid
uric (urat) d\u01b0\u1edbi da, t\u0103ng l\u01b0\u1ee3ng acid uric - m\u00e1u.

B\u1ec7nh n\u00e0y kh\u00e1c h\u1eb3n v\u1edbi b\u1ec7nh kh\u1edbp do tho\u00e1i h\u00f3a l\u00e0 b\u1ec7nh m\u1ea1n t\u00ednh c\u1ee7a kh\u1edbp v\u00e0 c\u1ed9t s\u1ed1ng c\u00f3 \u0111au v\u00e0 bi\u1ebfn d\u1ea1ng kh\u00f4ng c\u00f3 vi\u00eam. Th\u1ef1c ch\u1ea5t \u0111\u00e2y kh\u00f4ng ph\u1ea3i l\u00e0 b\u1ec7nh m\u00e0 l\u00e0 qu\u00e1 tr\u00ecnh gi\u00e0 h\u00f3a c\u1ee7a kh\u1edbp.

C\u00f3 th\u1ec3 x\u00e1c \u0111\u1ecbnh v\u00e0 ph\u00e2n bi\u1ec7t b\u1ec7nh gut v\u1edbi c\u00e1c b\u1ec7nh kh\u00e1c ch\u00ednh x\u00e1c d\u1ef1a v\u00e0o c\u00e1c bi\u1ec3u
hi\u1ec7n l\u00e2m s\u00e0ng song t\u1ed1t nh\u1ea5t n\u00ean l\u00e0m th\u00eam x\u00e9t nghi\u1ec7m v\u1ec1 n\u1ed3ng \u0111\u1ed9 acid uric - m\u00e1u v\u00e0 urat
ni\u1ec7u. B\u1ea1n c\u1ea7n kh\u00e1m x\u00e9t \u0111\u1ea7y \u0111\u1ee7, ch\u1ea9n \u0111o\u00e1n \u0111\u00fang b\u1ec7nh r\u1ed3i m\u1edbi d\u00f9ng thu\u1ed1c.

Thu\u1ed1c b\u1ea1n \u0111ang d\u00f9ng colchicin l\u00e0 thu\u1ed1c ch\u1eefa tri\u1ec7u ch\u1ee9ng. C\u1ea7n d\u00f9ng th\u00eam allopurinol l\u00e0
thu\u1ed1c ch\u1eefa nguy\u00ean nh\u00e2n.
Colchicin: D\u00f9ng m\u1ed9t m\u00ecnh ho\u1eb7c k\u1ebft h\u1ee3p v\u1edbi c\u00e1c ch\u1ea5t kh\u00e1ng vi\u00eam colchicin l\u00e0m gi\u1ea3m

tri\u1ec7u ch\u1ee9ng, ph\u00f2ng ng\u1eeba c\u00e1c hi\u1ec7n t\u01b0\u1ee3ng vi\u00eam t\u00e1i ph\u00e1t nh\u01b0ng kh\u00f4ng l\u00e0m h\u1ea1 \u0111\u01b0\u1ee3c acid uric trong m\u00e1u n\u00ean kh\u00f4ng ng\u0103n \u0111\u01b0\u1ee3c c\u00e1c bi\u1ebfn ch\u1ee9ng th\u1eadn v\u00e0 kh\u1edbp. T\u00ednh acid c\u1ee7a m\u00f4i tr\u01b0\u1eddng l\u00e0m k\u1ebft t\u1ee7a c\u00e1c tinh th\u1ec3 urat g\u00e2y n\u00ean b\u1ec7nh gut. Colchicin k\u00ecm h\u00e3m s\u1ef1 s\u1ea3n sinh acid lactic, \u1ed5n \u0111\u1ecbnh pH m\u00f4i tr\u01b0\u1eddng n\u00ean ch\u1eefa \u0111\u01b0\u1ee3c b\u1ec7nh gut.

Allopurinol: Enzym xanthin oxydase x\u00fac t\u00e1c s\u1ef1 t\u1ed5ng h\u1ee3p acid uric. Allopurinol \u1ee9c ch\u1ebf

enzym n\u00e0y do \u0111\u00f3 l\u00e0m gi\u1ea3m acid uric ni\u1ec7u v\u00e0 acid uric - m\u00e1u. Sau khi d\u00f9ng, thu\u1ed1c l\u00e0m
gi\u1ea3m acid uric - m\u00e1u trong v\u00f2ng 24 - 48 gi\u1edd. D\u00f9ng h\u00e0ng ng\u00e0y thu\u1ed1c s\u1ebd l\u00e0m gi\u1ea3m t\u1ed1i \u0111a
acid huy\u1ebft trong 2 tu\u1ea7n. Ng\u01b0ng d\u00f9ng thu\u1ed1c, acid uric - m\u00e1u tr\u1edf l\u1ea1i tr\u1ecb s\u1ed1 tr\u01b0\u1edbc \u0111\u00f3 trong
v\u00f2ng 7-10 ng\u00e0y. D\u00f9ng allopurinol \u0111\u1ec3 h\u1ea1 acid uric - m\u00e1u xu\u1ed1ng m\u1ee9c an to\u00e0n d\u01b0\u1edbi 430
micromol/l (t\u01b0\u01a1ng \u0111\u01b0\u01a1ng v\u1edbi 70mg/l\u00edt) nh\u1eb1m ng\u0103n ch\u1eb7n s\u1ef1 l\u1eafng \u0111\u1ecdng ura, tr\u00e1nh ho\u1eb7c
l\u00e0m ch\u1eadm s\u1ef1 xu\u1ea5t hi\u1ec7n b\u1ec7nh th\u1eadn. Ngo\u00e0i allopurinol c\u0169ng c\u00f3 th\u1ec3 d\u00f9ng v\u00e0i lo\u1ea1i thu\u1ed1c kh\u00e1c
nh\u01b0 desuric, benemid nh\u1eb1m \u0111\u00e0o th\u1ea3i acid uric qua \u0111\u01b0\u1eddng ti\u1ec3u. T\u1ea5t nhi\u00ean c\u00e1c thu\u1ed1c n\u00e0y
kh\u00f4ng c\u00f3 t\u00e1c d\u1ee5ng ch\u1ee7 \u0111\u1ed9ng nh\u01b0 allopurinol.

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