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Dna Markers

Dna Markers



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Published by: api-3839553 on Oct 18, 2008
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BIO4320 Lecture Materials, Prepared by Dr. Hon-Ming Lam
Molecular Markers Used inGenome Mapping
Further Readings:“Genome II”by T.A. Brown, Ch. 2 and 5“DNA Fingerprintingby M. KrawczakandJ. Schmidtke, Ch. 2 & 5“DNA Fingerprinting in Plants and Fungi”by K. Weising, et al., Ch.2
BIO4320 Lecture Materials, Prepared by Dr. Hon-Ming Lam
Genetic map – based on genetic techniques such ascross-breeding or pedigrees – calculation of map distance based onrecombination frequenciesPhysical map – examine DNA molecules directly toshow the relative positions of sequencefeatures – the ultimate physical map is the DNAsequence of the whole genome
Two Major Kinds of Genome Mapping
BIO4320 Lecture Materials, Prepared by Dr. Hon-Ming Lam
Markers for Genetic Mapping
Phenotypic (morphological) markers:based onpolymorphism in physical appearance, e.g. flowercolor, leaf shape, seed coat, etc.Cytological markers:based on the structure andnumber of chromosomes, e.g. deletion,duplication, inversion, translocation, etc.Biochemical markers: – Macromolecules: technically difficult – Isozymes(allozymes=isozymesencoded bydifferent alleles of the same gene): easilyvisualized by activity gels, etc.

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