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IL-6 and RA Julio 08

IL-6 and RA Julio 08

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Published by: api-3826239 on Oct 18, 2008
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05/09/2014

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IL-6R: A logical target in RA
Dr Ernest Choy
King\u2019s College Hospital,
London, UK
En la red de citocinas que participan en RA
la IL-6 juega un papel central
Firestein GS.N at ure 2003;423:356\u2013361; Smolen JS and Steiner G. Nat Rev Drug Disc 2003;2:473\u2013488.
IL-6
Macrophage
IL-18
IL-15
Cartilage
Osteoclas
t
Bone
Chondrocyte
RANKL
FGF
TGF\u03b2
IL-8
Fibroblast

Acute-phase
proteins
Hepcidin

IL-17
IFN\u03b3
T cell
sTNFR, TNF-\u03b1
IL-10, IL-1, IL-18, IL-IR
B cell
Liver
Rheumatoid
factor
IL-6
IL-6 has both articular and systemic
effects in RA
Articular effects
\u2022Pannus formation
\u2013IL-6 induces VEGF production
\u2022Bone
\u2013IL-6 is known to promote osteoclast maturation and activation
\u2013IL-6 may be crucial in mediating the impact of chronic inflammation
Systemic effects
\u2022Liver
\u2013IL-6 is the chief stimulator of acute phase proteins
\u2013IL-6 induces hepatocyte proliferation
\u2022Anaemia
\u2013Chronic inflammatory diseases are characterised by anaemia
\u2013A clear association between IL-6 and anaemia has been shown
\u2022Lipids and lipid metabolism
\u2013IL-6 can stimulate both hepatic fatty acid synthesis and adipose tissue
lipolysis

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