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NanobiotechnologyII

NanobiotechnologyII

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Published by: api-3722267 on Oct 19, 2008
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03/18/2014

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Part I
Self-Assembly and Nanoparticles:
Novel Principles

Nanobiotechnology II. Edited by Chad A. Mirkin and Christof M. Niemeyer
Copyright8 2007 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
ISBN: 978-3-527-31673-1
1Self-Assembled Arti\ufb01cial Transmembrane Ion
Channels
Mary S. Gin, Emily G. Schmidt, and Pinaki Talukdar
1.1
Overview

Natural ion channels are large, complex proteins that span lipid membranes and allow ions to pass in and out of cells. These multimeric channel assemblies are capable of performing the complex tasks of opening and closing in response to speci\ufb01c signals (gating) and allowing only certain ions to pass through (selectiv- ity). This controlled transport of ions is essential for the regulation of both intra- cellular ion concentration and the transmembrane potential. Ion channels play an important role in many biological processes, including sensory transduction, cell proliferation, and blood-pressure regulation; abnormally functioning channels have been implicated in causing a number of diseases [1]. In addition to large ion channel proteins, peptides (e.g., gramicidin A) and natural small-molecule antibiotics (e.g., amphotericin B and nystatin) form ion channels in lipid mem- branes.

Due to the complexity of channel proteins, numerous research groups have during recent years been striving to develop arti\ufb01cial analogues [2\u20137]. Initially, the synthetic approach to ion channels was aimed at elucidating the minimal structural requirements for ion \ufb02ow across a membrane. However, more recently the focus has shifted to the development of synthetic channels that are gated, pro- viding a means of controlling whether the channels are open or closed. Such arti- \ufb01cial signal transduction could have broad applications to nanoscale device tech- nology. In this chapter we will present examples of some strategies used in the development of arti\ufb01cial ion channels, and describe some techniques commonly used to evaluate their function.

1.1.1
Non-Gated Channels
The arti\ufb01cial ion channels described to date can be divided into two major classes.
The \ufb01rst class consists of non-gated channels, which are synthetic compounds
3
Nanobiotechnology II. Edited by Chad A. Mirkin and Christof M. Niemeyer
Copyright8 2007 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
ISBN: 978-3-527-31673-1

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