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[ATB] Penicilinas 2007

[ATB] Penicilinas 2007

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Published by: api-3697245 on Oct 19, 2008
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03/18/2014

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PENICILINAS
\u00df-lact\u00e1micos \u2013 Estructura Qu\u00edmica
PENICILINAS
\ue000Descubrimiento: 1929 A. Fleming, sobre S. aureus
\ue000Estructura b\u00e1sica: Anillo de tiazolidina + anillo \u00df
lact\u00e1mico y cadena lateral

\ue000Destrucci\u00f3n por acidez g\u00e1strica (mayor\u00eda)
\ue000Escaso o ning\u00fan metabolismo
\ue000Excreci\u00f3n renal (filtraci\u00f3n + secreci\u00f3n)
\ue000Acci\u00f3n Bactericida (tiempo dependiente)
\ue000Resistencia: -\u00df- lactamasas

-Disminuci\u00f3n de permeabilidad
-PBP con menor afinidad

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