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\ue000Pathological states (KI / LV dz)
\ue000Psycological state (placebo responder)
\ue000Physiologic factors (drug metabolism)
\ue000Lipophilic molecules rapidly pass placenta
\ue000Hydrophobic drugs slow to cross placenta
\ue000Placenta is barrier to some drugs
\ue000Fetus can only eliminate drugs slowly and will re-
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