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Pharmaceutical Calculations

# Pharmaceutical Calculations

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sample problems for FPGEE
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03/18/2014

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Pharmaceutical Calculations
1. How much Lidocaine is required to prepare 1 : 1000, 30 cc of solution
of Lidocaine?

a. 10 mg
b. 0.03 mg
c. 30 mg
d. 300 mg

2. How many cc of 75 % alcohol should mix with 10 % of 1000cc alcohol
to prepare 30% of 500cc alcohol solution?

a. 346.16 cc b. 234.43 cc c. 153.84 cc d. 121.12 cc

3. If 60 gm of 1% hydrocortisone is mixed with 80 gm of 2.5% of
hydrocortisone, what is the % of hydrocortisone in final mixture?

a. 2.2 % w/w
b. 1.85 % w/w
c. 0.25 % w/w
d. 1.75 % w/w

4. If 1000 tablets of Risperdal 1 mg cost \$ 2250 and % mark up on
prescription is 20, what would be the retail price of 30 tablets?

a. \$ 150
b. \$ 17
c. \$ 500
d. \$ 81

5. If the ratio of ionized to unionized species of drug is 103 and PKa =
2.2, what is the PH of the solution?

a. 2.2 b. 0.8 c. 5.2 d. 3.0

6. If dropper is calibrated to deliver 325 mg of iron sulfate in 0.6 cc and adult dose of drug is 325 mg , what is the dose of a drug in cc for a 15 months-old infant?

a. 1.2 cc
b. 0.3 cc
c. 0.06 cc
d. 0.01 cc

7. If the dose of a drug is 10 mg/kg/day, how many 250 mg/100cc ready
infusion-bags require to fill above order? Patient's weight is 156 lbs.

a. 1 bag
b. 2 bags
c. 3 bags
d. 5 bags

8. How much of atropine is required to prepare 240cc in such way that
when 1 teaspoonful of the solution is diluted to 1 pint gives 1 in 500
solution?

a. 2.25 gm
b. 46.08 gm
c. 35.15 gm
d. 25.35 gm

9. How much sodium bicarbonate powder is required to prepare 240cc of
0.10 N solution of sodium bicarbonate?

a. 1.35 gm
b. 3.25 gm
c. 4.81 gm
d. 2.016 gm

10. How many meq of Na+ are present in 0.9% 250cc normal saline
solution? [Na+ = 23, Cl- = 35.5]

a. 23.12 meq b. 15.17 meq c. 53.15 meq d. 38.46 meq

11. If the probability of success in Null hypothesis is 0.6, what is the
probability of failure?

a. 0.3 b. 0.9 c. 0.6 d. 0.4

12. How many grams of cocabutter are required to dispense 12
suppositories of tannic acid each weighing 2 gm and contain 400 mg of
tannic acid?

a. 21.23 gm b. 18.67 gm c. 14.12 gm d. 13.25 gm

13. What is the "mode" or "median" of the following values?
120, 135, 140, 118, 175, 105, 115, 190
a. 135
b. 118
c. 127.5
d. 175
14. If the concentration of reactant M is half in a reaction that is third
order in M, by what factor will rate of reaction change?

a. 1/8 times
b. 1/4 times
c. 8 times
d. 4 times

15. What is the rate of constant after 90 minutes if the initial
concentration of drug is 500mg/cc and 50mg/cc after 90 minutes? (First
Order Kinetic)

a. 0.051 min-1
b. 0.025 min-1
c. 0.35 min-1
d. 0.86 min-1

16. If the total body clearance of the patient is 2100cc/hr and hepatic
clearance is 300cc /hr, what is the status of renal function in a patient?

a. Excellent
b. Normal
c. Moderately impaired
d. Severely impaired

17. How many grams of sodium chloride are required to prepare 250cc
of 1% boric acid solution to isotonic with eye tears?