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Fpgee test practice

Fpgee test practice

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Published by: api-3830277 on Oct 19, 2008
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05/09/2014

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Question 1
The right answer was
The removal of drug is independent of drug concentration.
Question 2
The right answer was
Excretion rate.
Question 3
The answer is Extraction ratio
Question 4
The right answer was
 All are correct.
Question 5
The right answer was
2.4 mg.
Question 6
The right answer was
1.25 mg.
Question 7
The right answer was
30 L/hr/70 Kg.
Question 8
The right answer was
a & b.
Question 9
The right answer id CYP51
Question 10
The right answer was
CYP51.
Question 11
The right answer was
 All of the above.
Question 12
The right answer was
Both carry out oxidative deaminations.
Question 13
The right answer was
Glucuronide conjugation.
Question 14
The right answer was
Hydroxylation.
Question 15
The right answer was
Decrease.
 
In a zero order elimination process, which of thefollowing is true?
The removal of drug is independent of drug concentration
Cl = Elimination rate/Cp
t1/2 = .7VD/Cl
All are true
For highly polar drugs (e.g. mannitol) what primarilydetermines elimination rate?
Excretion rate
Metabolism rate
Absorption rate
Distribution rate
All of the above
Bioavailability is related to which of the followingparameters, according to the equation F = 1 - E
Excretion
Elimination
Extraction Ratio
Enterohepatic Recycling
For the majority of drugs, which of the followingequations correctly defines clearance?
 
Cl = Elimination rate/Cp
Cl = QxE
Cl = .7VD/t1/2
All are correct
How much of a 10 mg dose of morphine reaches thesystemic circulation given F = .24?
24mg
0.24 mg
2.4 mg
4.1 mg
Given that the VD = 230 L/70Kg and Cl = 60 L/hr/70Kg for morphine, approximately how much of a 10 mgIV dose remains after 8 hr, given to a normal 70 Kgpatient?
5 mg
2.5 mg
1.25 mg
625 mg
Given F = .24, what is the overall hepatic clearance of morphineif the above patient has portal hypertension such that theirhepatic blood flow is reduced by ½? Assume the clearancevalue given in the previous question is entirely hepaticclearance.

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