This is a transcript of an interview with Dr. Rolf Hoffman, CMO of RepliCel Life Sciences, Inc.Those of us who treat hair loss are watching the development of "hair cloning" technology with the hope that this research may add some insight into the workings of the hair follicle. We also wonder whether this may turn into a viable treatment optionas an adjunct to the safe and effective medical and surgical treatments currently available today.--Dr. Alan J. Bauman, M.D.Medical Director - Bauman Medical Group, P.A. Boca Raton, FLDiplomate, American Board of Hair Restoration Surgery
Equities Interview with Dr. Rolf Hoffmann, Chief Medical Officer, RepliCel Life Sciences Inc.November 22, 2011Effective treatment for hair loss has advanced considerably over the past several decades,but for all that the multi-billion dollar industry has become, there still lacks a truly viableand permanent solution that addresses the needs of both men and women. For biotechcompany RepliCel Life Sciences, Inc.(REPCF), promising research around the regenerative properties of dermal sheath cup cellscould prove to be the break-through that millions of hair-loss suffers have been waiting for.For over a decade, leading hair biology scientists, Dr. Rolf Hoffmann and Dr. KevinMcElwee, have been studying the potential of dermal sheath cup cells to spark hairregeneration and the rejuvenation of miniaturized hair follicles. Hoffmann, RepliCel's Chief Medical Officer, discusses his research, the process of developing this treatment, and thecritical steps the company is taking along the way to ensure that it is successful.EQ: Can you start off by briefly talking about the history of your research and when yourealized it had this kind of potential?Hoffmann: Back in 1999, Dr. Kevin McElwee was the "postdoc" in my lab, and we found that the specific area on the very deep part of the hair follicle--what we call the "hair cup"--hasthe potential to regenerate hair in animals. So we studied this hypothesis on mice and it showed that the cells, when implanted, traveled to existing hair follicles and made thembigger. In addition, those cells alone, with no other mixture of cells, were able to induce thegrowth of hair follicles in the palms and soles of the mice, showing that these cells wereable to generate hairs de novo (anew). So we conducted our studies in1999 - 2001 and published it in 2003. It's nice to have the animal data, but of course, wewanted to translate it to humans.