Baøi Giaûng daønh cho

Ñoái töôïng: Sinh vieân ÑH BK, Ngaønh Vaät Lyù Kyõ Thuaät Y Sinh.
Naêm hoïc 2007

BỆNH MÔ LYMPHÔ

Thaïc só Baùc só HUYØNH NGOÏC LINH

Boä moân MOÂ – PHOÂI – GIAÛI PHAÃU
BEÄNH
TRUNG TAÂM ÑAØO TAÏO CAÙN BOÄ Y
TEÁ TP.HCM
 VÒ TRÍ MOÂ LIMPHOÂ

Tuyeán öùc, haïch

limphoâ vaø
laùch
Amygdales, suøi VA
(veùgeùtation
adeùnoïde) vaø
maûng Peyer
Tuûy xöông, phoåi,
oáng tieâu
hoùa
Haïch limphoâ
 Sinh thieát
Haïch
• Laáy maåu moâ haïch
töø ngöôøi soáng xeùt
nghieäm
• Coù yù nghóa trong
chaån ñoaùn u
nguyeân phaùt vaø di
caên…
TB goác  Tieàn teá baøo B  limphoâ baøo B1 
teá baøo trung

gian  töông baøo  Limphoâ baøo B2

  

Nguyeân baøo
mieãn dòch B

( Nguyeân taâm baøo, Taâm baøo )

Tieàn teá baøo T  limphoâ baøo T1  Nguyeân

baøo mieãn dòch T  Limphoâ baøo T2
 BEÄNH HAÏCH LIMPHOÂ

• 1. VIEÂM HAÏCH : caáp, maïn. Ñaëc hieäu

hoaëc khoâng
• 2. TAÊNG SAÛN : nang, xoang
• 3. LIMPHOÂM : Hodgkin, khoâng Hodgkin
• 4. UNG THÖ DI CAÊN HAÏCH
 VIEÂM HAÏCH

1. KHOÂNG ÑAËC HIEÄU:

1.1 Caáp: vieâm nhieãm, u. haïch söng to ñau. Maët caét
traéng xaùm. Xoang haïch daõn, phuø, nang limphoâ taêng
saûn, trung taâm maàm to, nhieàu thöïc baøo
1.2. Maïn: sau vieâm caáp, vieâm taùi phaùt. Vd: haïch döôùi
haøm vaø vieâm trong oå mieäng.
2. ÑAËC HIEÄU:
- LAO HAÏCH: Mycobacterium Tuberculosis. Thöôøng gaëp ôû
VN. Thöôøng ôû coå vaø naùch, doø ra da hoaïi töû baõ
ñaäu. Vi theå: nang lao
- GIANG MAI: Treponema pallidum. Thôøi kyø 1 hay 2. Taêng
saûn nang limphoâ, coù nhieàu thöïc baøo.
ACUTE LYMPHADENITIS
LAO HẠCH
MỤN NHIỄM
GIANG MAI
Syphilitic lymphadenitis
Histopathology showing Treponema pallidum spirochetes
in testis.
Modified Steiner silver stain.
 Syphilis

Treponema pallidum
 PHAÛN ÖÙNG TAÊNG SAÛN
HAÏCH
• 1. TAÊNG SAÛN NANG: thöôøng ôû treû
em, do kích thích ñaùp öùng mieãn dòch
theå dòch hoaït ñoäng, coù theå do
nguyeân nhaân nhieãm truøng.
• Vi theå: vuøng B to, taêng saûn trung
taâm maàm, hình daïng kích thöôùc
khoâng ñeàu, trong nang taêng phaân
baøo.

• 2. TAÊNG SAÛN XOANG: haïch daãn löu

vieâm hay ung thö.
• Vi theå: Xoang haïch daõn roäng keøm
REACTIVE FOLLICULAR HYPERPLASIA
REACTIVE FOLLICULAR HYPERPLASIA
Sinus
Histiocytosis
"Hodgkin's Disease" (named after Dr. Thomas
Hodgkin (1798 – 1866) , who first recognized it in
1832)
 Hodgkin's Disease - Classification

Type Histologic Features Frequency Prognosis

Lymphocyte
Good, most are
predominance Mostly B-cells and few Uncommon
stage I or II
(type 1) Reed-Sternberg variant cells

Nodular Most frequent type, more common in Good, most are

sclerosis (type 2) Bands of fibrosis, lacunar cells women stage I or II

Composed of many different Most frequent in older persons, Fair, most are
Mixed cellularity
cells second most frequent overall stage III
(type 3)

Lymphocyte
Many Reed-Sternberg cells and Poor, most are
depletion Uncommon
variants stage III or IV
(type 4)
African Burkitt's lymphoma

Dennis Burkitt's first description of

the African tumor that is now known
by his name appeared in 1958.

In addition, epidemiological
considerations led to the
discovery of a new virus, the
Epstein-Barr virus, which has
proved to be an important
human pathogen.

Central Africa: Uganda

“starry sky” pattern

A type of non-Hodgkin's lymphoma that often occurs in children or young adults

BURKITT’S LYMPHOMA
FOLLLICULAR
LYMPHOMA
FOLLLICULAR LYMPHOMA
T cell Lymphoma
 UNG THÖ DI CAÊN HAÏCH

• Xuaát ñoä cao hôn ung thö nguyeân phaùt

ôû haïch. Carcinoâm teá baøo gai voøm
haàu, ñöôøng hoâ haáp treân, coå töû
cung, döông vaät hay carcinoâm tuyeán
ôû vuù, ñöôøng tieâu hoùa, phoåi…
• ÔÛ treû em u nguyeân baøo thöôøng di
caên haïch.
• Haïch phì ñaïi, khoâng ñau, thöôøng ôû
vuøng coå, naùch, beïn. Moâ ñaëc, chaéc,
maøu traéng xaùm.
• Vi theå: caáu truùc haïch coøn nguyeân
Xin chaân thaønh
CHAÂN caûm ôn
THAØNH
CAÛM ÔN