DALAM PENGEMBANGAN OBAT HERBAL Oleh : Maksum Radji Abstrack Plants have been the chieI source oI compounds oI medicine Ior thousand oI years. Plants are also the source oI many medicines Ior the majority oI the world`s population. The role oI biotechnology is very important Ior multiplying, conserving the spesies, and enhancing the production oI secondary metabolites. Endophytes aremicrobes that inhabit plants are currently considered to be a wellspring oI novel secondary metabolites oIIering the potensial Ior medical and industrial exploitation. Natural products Irom various endophytic microbes have been investigated. Some examples oI natural products observed Irom endophytic microbes are antibiotics, antiviral compounds, anticancers, antimalarial compounds, antioxidants, antidiabetics, and immunosuppressive compounds. Key words : secondary metabolites, endophytes, genetic engineering, tissue culture