IAY, J. TUSZYNSKI AND ¥.K. TAM.
the Area Under the Curve. The
of the body and
Wwe drug. from the plast
‘drug removed depends on the plasma concent
Clearance can be measured as « proportion
Ri, = Retnination = Ch + Cu
dosage forms provides addi
and intrinsic clearance. These di
Physiologi
of compartments representing
1g by in
xy, depending on the precision and accuracy of the methods used
Absorption
routes of admi
which involves the r y
the cutaneous structure, of iv, injection.
throughout the body to various organs and
ing the transport of the drug between the various defined compartme
movement ix xed to be limited within the blood [8]
REASSESSI
‘PAI
CTRACTION: 3
is homogeneous and that the phys
in the compart
‘equations (ODEs) with
fer approach assumes tlnued popularity of multi-compartment models of phan
sticle we compare and contrast several
concept of interconnected compartments. Our obje
sy of providing 4 correla
studied
: the well-sirred, the p
the Vou and Kyy
1 hepatocyte preparation. This kinetic data
‘must then be
sed to predict the to
st TVIVE work assumes
exposed to the same drug concentr
stand and work with, and produces res
hat they bel
siosing sinusoids, The
administration I
review unticles
‘We apply our technique to drugs taken from two Houston
LIVER MODELS
There are a substant
J.A. Tuszynski, J.A. Brown, E. Crawford, E.J. Carpenter, M.L.A. Nip, J.M. Dixon and M.V. Sataric: Molecular Dynamics Simulations of Tubulin Structure and Calculations of Electrostatic Properties of Microtubules