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The Current Evidence-Based Medicine Landscape

The Current Evidence-Based Medicine Landscape

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This reference guide identifies and documents all relevant organizations, activities, proposals, and key individuals associated with the evidence movement in the U.S., including anything of note under the rubric of evidence-based medicine (EBM), comparative effectiveness, health (or medical) technology assessment (HTA), etc.
This reference guide identifies and documents all relevant organizations, activities, proposals, and key individuals associated with the evidence movement in the U.S., including anything of note under the rubric of evidence-based medicine (EBM), comparative effectiveness, health (or medical) technology assessment (HTA), etc.

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Published by: National Pharmaceutical Council on Oct 28, 2008
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Report Prepared for:National Pharmaceutical Council
Prepared by:
Bryan R. Luce, PhD, MBARebecca Singer Cohen, MPPCraig Hunter, MPP, PGDPLael Cragin, MPHJeanene Johnson, BAApril 2008
THE CURRENT EVIDENCE-BASED MEDICINE LANDSCAPE
7101 Wisconsin AvenueSuite 600Bethesda, MD 20814Phone: 1-301-654-9729Fax: 1-301-654-9864www.UnitedBioSource.com
 
The Current Evidence- Based Medicine LandscapeNational Pharmaceutical Council
1
TABLE OF CONTENTS
INTRODUCTION
 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .4
I. GOVERNMENT INITIATIVES
 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .5Agency for Healthcare Research and Quality (AHRQ) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .5AHRQ Organizational Structure . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .5National Advisory Council for Healthcare Research and Quality . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .6U.S.Preventive Services Task Force (USPSTF) Program . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .9Evidence-Based Practice Center (EPC) Program . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .12Effective Health Care (EHC) Program . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .15Comparative Effectiveness Reviews (CERs) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .18Centers for Education & Research on Therapeutics (CERT) Program . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .22CMS’s Coverage with Evidence Development . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .24Coverage with Appropriateness Determination (CAD) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .24Coverage with Study Participation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .25Data Sources . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .26HHS Value-Driven Health Care Initiative . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .27Chronic Conditions Data Warehouse (CCW) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .27The Department ofDefense PharmacoEconomic Center (PEC) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .28Veterans Affairs Technology Assessment Program (VATAP) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .28National Institutes ofHealth- Clinical and Translational Science Awards (CTSA) . . . . . . . . . . . . . . . . . . . . . . .28National Institutes ofHealth- Antihypertensive and Lipid Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .29National Institutes ofHealth- Clinical Antipsychotic Trials ofIntervention Effectiveness (CATIE) . . . . . . . . .30Centers for Disease Control and Prevention- Evaluation ofGenomic Applicationin Practice and Prevention (EGAPP) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .30Oregon Health & Science University Drug Effectiveness Review Project (DERP) . . . . . . . . . . . . . . . . . . . . . . . .31Medicaid Evidence-Based Decisions Project (MED) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .33Washington State Health Technology Assessment Program (SHTAP) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .33
II. PROPOSALS FOR COMPARATIVE EFFECTIVENESS CENTERS
 . . . . . . . . . . . . . . . . . . . . . . . . . .34Gail Wilensky’s Proposed Center for Comparative Effectiveness . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .34Blue Cross and Blue Shield Association Proposed Payer-Funded Center for Comparative Effectiveness . . . . .34Enhanced Health Care Value for All Act of2007 (H.R.2184) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .35S.3,Medicare Prescription Drug Price Negotiation Act of2007 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .37H.R.3162:The Children’s Health and Medicare Protection Act of2007 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .38Baucus/Conrad Senate bill:Introduced and Withdrawn March 4,2008 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .40Congressional Budget Office report . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .40
III. PRIVATE INITIATIVES
 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .41America’s Health Insurance Plans (AHIP) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .41Center for Medical Technology Policy (CMTP) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .41Institute for Clinical and Economic Review (ICER) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .43
 
National Pharmaceutical CouncilThe Current Evidence- Based Medicine Landscape
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IV. INDEPENDENT EVIDENCE-BASED MEDICINE INITIATIVES
 . . . . . . . . . . . . . . . . . . . . . . . . . . . .44Institute ofMedicine (IOM) Roundtable on Evidence-Based Medicine . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .44The James Lind Alliance . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .46The Cochrane Collaboration . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .46ECRI Institute . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .47Hayes,Inc.– The Health Technology Assessment Company . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .48AcademyHealth Support ofComparative Effectiveness Research . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .48Academy ofManaged Care Pharmacy’s Format for Formulary Submissions . . . . . . . . . . . . . . . . . . . . . . . . . . . .48
V. CONSUMER-FOCUSED INITIATIVES
 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .49Consumer Reports Best Buy Drugs . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .49American Association ofRetired Persons (AARP) ResearchRx . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .51Alliance for Better Medicine . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .51National Working Group on Evidence-Based Healthcare . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .51US Cochrane Collaboration’s Consumers United for Evidence-based Healthcare (CUE) . . . . . . . . . . . . . . . . .52
VI. MEASURING VALUE IN HEALTH CARE: Standardizing Metrics
 . . . . . . . . . . . . . . . . . . . . . .54National Committee for Quality Assurance (NCQA) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .54The Health Plan Employer Data and Information Set (HEDIS) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .55Pharmacy Quality Alliance . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .55
VII. INTERNATIONAL
 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .57U.K.’s National Institute for Health and Clinical Excellence (NICE) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .57Canadian Agency for Drugs and Technologies in Health (CADTH) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .57Australia’s Pharmaceutical Benefits Advisory Committee (PBAC) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .58Germany’s Institute for Quality and Efficiency in Health Care (IQWiG) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .58The International Network ofAgencies for Health Technology Assessment (INAHTA) . . . . . . . . . . . . . . . . . . .58Health Technology Assessment International (HTAi) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .59The OECD Health Care Quality Indicators Project . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .59
VIII. EVIDENCE-BASED MEDICINE CONGRESSES
 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .60October 2006 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .60November 2006 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .61January 2007 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .62February 2007 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .62March 2007 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .63April 2007 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .64May 2007 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .65June 2007 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .69July 2007 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .71August 2007 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .72September 2007 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .73October 2007 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .74December 2007 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .76

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