Dopa: Dihydroxyphenyl alanine.
Types of catecholamine: Dopamine, Norepinephrine andEpinephrine.
Dopamine doesn't contain a hydroxyl group on C (take a look at thefigure).
Norepinephrine contains a hydroxyl group on C. This hydroxyl group(which is found in norepinephrine but not in dopamine) makes manydifferences between norepinephrine and dopamine: differentreceptors, actions and locations.
If we methylate the amine group in norepinephrine (nor methyl) wewill have epinephrine. This methyl group makes the Epinephrinemore selective to the
-receptors than norepinephrine. (More bulk
more selective for
(in the same figure)-
It is taken up by the same transport mechanisms forcatecholamines and get stored in the vesicles.-
It displaces catecholamine.-
At the beginning, tyramine released into the vesicles in largenumbers causing hypertensive crises (due to the large amount).-
Synthesized in the body but in small amounts. Found also in: cheese(especially stored cheese) and wine. If the person eats too much