Muscle Fatigue

Muscle cause
Extended submaximal exertion
Glycogen depletion Decrease of Ca++ release

Short duration maximal exertion

Increased production of Pi slow release of Pi from myosin alter the power stroke K+ leaves the cell with each AP alter membrane potential of the muscle fiber Ca++ release from sarcoplasmic reticulum

Lactic acid

Neuronal cause
Communication failure in n-m junction CNS command failure The synthesis of ACh outpaced the firing rate of the neuron muscle end-plate potential may fail to reach the threshold

EXERCISE-ASSOCIATED MUSCLE CRAMPING

Definition: painful, spasmodic, involuntary contraction of skeletal muscle that occurs during or immediately after exercise Hypothesis: a result of an abnormality of sustained alpha motor neuron activity, which stems from aberrant control at the spinal level Contributing factors:
muscle fatigue contraction of the muscle in its shortest position (inner range)

Skeletal Muscle Cramps During Exercise Martin P. Schwellnus, MBBCh, MSc (Med), MD THE PHYSICIAN AND SPORTSMEDICINE - VOL 27 - NO. 12 - NOVEMBER 1999