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Pharmaceutical Suspensions

Pharmaceutical Suspensions

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Published by Usman Akhtar

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Published by: Usman Akhtar on Dec 19, 2011
Copyright:Attribution Non-commercial

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05/31/2013

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RAHAT SHAMIM
 
Definition:
Suspensions are heterogeneous systems consisting of twophases. The continuous or external phase is generally aliquid or semisolid, and the dispersed or internal phase ismade up of particulate matter that is essentially insolublein but dispersed throughout the continuous phase theinsoluble matter may be intended for physiologicabsorption or for internal or external coating functions.
Preparations containing finely divided drug particles(suspensoid) distributed somewhat uniformly throughouta vehicle in which the drug exhibits the minimum degree of solubility.
 A coarse suspension is a dispersion of finely dividedinsoluble solid particles in a fluid.
 
Systems with particles smaller than 0.1 to 0.2 micron aregenerally considered to be colloidal and exhibit propertiesthat lie between those of true molecular solutions andsuspensions of visible particles do not exhibit all propertiesof colloid
The suspended particles do not exhibit all properties ocolloids, such as colligative properties but do have surfaceproperties which enhances its adsorption power.
Dispersed particles in the coarse dispersion have a greatertendency to separate from the dispersion medium becauseof their greater size than in fine dispersions.
Most solids in dispersion tend to settle to the bottom of container due to greater density than dispersion medium.
Complete and uniform redistribution of the dispersedphase is essential to the accurate administration of uniformdoses.

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