Increasing the inhibitory activity of GABA that causes increased influx of chloride ions that, in turn, decreases neural excitation by hyperpolarizationand elevated seizure threshold.
Clonazepam, Valproic acid, Phenobarbital, Vigabatrin, Tiagabine,Felbamate, Gabapentin, Pregabalin, Topiramate
Reducing the propagation of abnormal electrical activity in the brain byinhibiting the T-type calcium channels.
EthosuximidePrimary Drugs for Epilepsy
A BZD which suppresses seizure spread from the epileptogenic foci byenhancing GABA action.
Valproic acid (Depakene)
A carboxylic acid derivative that acts by increasing the inhibitory activityof GABA by inhibiting 2 enzymes that inactivates GABA: (1) GABA-transaminase and (2) succinic semialdehyde dehydrogenase.
Also known as diphenylhydantoin or DPH.
Oldest non-sedating drug that acts by inhibiting sodium channel functionand increasing GABA action.
A derivative of barbituric acid that inhibits initiation of discharge,elevates seizure threshold, and potentiates inhibitory pathways in thebrain by enhancing GABA action.
Drug of choice for neonatal and febrile seizures.
Also known as 2-desoxyphenobarbital.
A derivative of barbituric acid which is metabolized to activeanticonvulsants: phenobarbital and phenylethylmalonamide (PEMA).
Acts by inhibition of sodium channel function.
A tricyclic compound used also in treating bipolar depression.
Acts by inhibiting sodium channel function, thus inhibiting the generationof repetitive action potentials in the epileptic focus.
A succinimide, pure petit mal drug.
Reduces the propagation of abnormal electrical activity in the brain byinhibiting the T-type calcium channels.Newer Anti-epileptic drugs
gamma-vinyl-substituted analogue of GABA.
Irreversibly inhibits the GABA metabolizing enzyme, GABAaminotransferase (GABA-T), thereby enhancing the inhibitory effect of GABA.
Acts by inhibiting sodium channels.