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STABILITASOBAT

STABILITASOBAT

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Published by novi_lingga

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Published by: novi_lingga on Dec 28, 2011
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11/07/2012

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Drug Stability
 
3
DEKOMPOSISI DAN STABILISASI BAHAN OBAT
DEKOMPOSISI:
HIDROLISIS :Ampisilin: dekomposisi pada pH 8-10,stabilitas maksimum dalamlarutan dapar pada pH 4,85 dan dalam larutan nondapar pH 5,85Kloramfenikol: laju degradasi lambat pada pH 2-7, stabilitasmaksimum pada pH 6.Eritromisin: Paling stabil dalam dapar fosfat , kurang stabil dalamdapar natrium asetat .Triamsinolon asetinoida: stabil pada pH 3,4. Dalam dapar HClterurai menjadi triamsinolon dan aseton.Vinkristin: paling stabil pada pH 3,5 dan 5,5 suhu 80
0
C.
OKSIDASI:Asam askorbat: maksimum degradasi pH 4 minimum pH 5,6dalam dapar sitrat-fosfat.

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