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LSM2102 Molecular Biology

Regulation of Eukaryotic gene expression Adam Yuan dbsyya@nus.edu.sg adam@tll.org.sg

Main textbook
Alberts et al. (2008) Molecular Biology of Cell (5th Edition) or (4th Edition, 2002) Chapter 6, How cells read the genome: from DNA to protein Chapter 7, Control of gene expression. Chapter 22, Development of multicellular organisms

Argonaute structures

Importance of RNA silencing


RNAi occurs in plants, animals, and humans Function: Gene expression regulation Viral infections defense Jumping gene control Biotechnology Tools: Gene function study Novel therapies in the future Andrew Z. Fire Craig C. Mello

The Nobel Prize in Physiology or Medicine 2006 "for their discovery of RNA interference - gene silencing by double-stranded RNA"

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