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  • Animal Models of Metastasis: Jos Jonkers

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    Ersin Kamburoğlu
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    This document introduces the topic of using animal models to study metastasis in cancer research. It notes that metastasis is the major cause of cancer death and is a complex process influenced by molecular events and host factors. The introduction states that realistic animal models are needed to better understand the mechanisms and tumor-host interactions that drive metastasis formation. The session will feature experts discussing metastasis in genetically engineered mouse models of major human cancers, focusing on metastasis-propagating cells, cancer cell dissemination, and the role of host factors in metastasis.

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    This document introduces the topic of using animal models to study metastasis in cancer research. It notes that metastasis is the major cause of cancer death and is a complex process influenced by molecular events and host factors. The introduction states that realistic animal models are needed to better understand the mechanisms and tumor-host interactions that drive metastasis formation. The session will feature experts discussing metastasis in genetically engineered mouse models of major human cancers, focusing on metastasis-propagating cells, cancer cell dissemination, and the role of host factors in metastasis.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as PDF, TXT or read online from Scribd
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    18 views1 page

    Animal Models of Metastasis: Jos Jonkers

    Uploaded by

    Ersin Kamburoğlu
    This document introduces the topic of using animal models to study metastasis in cancer research. It notes that metastasis is the major cause of cancer death and is a complex process influenced by molecular events and host factors. The introduction states that realistic animal models are needed to better understand the mechanisms and tumor-host interactions that drive metastasis formation. The session will feature experts discussing metastasis in genetically engineered mouse models of major human cancers, focusing on metastasis-propagating cells, cancer cell dissemination, and the role of host factors in metastasis.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as PDF, TXT or read online from Scribd
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    Animal Models of Metastasis

    Introduction
    Jos Jonkers
    Metastatic disease is the major cause of death in cancer patients. Metastasis is the result of a complex set of molecular events whose outcome is eventually disseminated disease. Moreover, metastasis development is influenced by a number of host factors, including stromal cells as well as innate and adaptive immune cells. This complexity has made it difficult to identify the molecular mechanisms driving the metastatic process and has confounded our understanding of how and when therapeutic intervention can be effectively used. Delineation of the mechanisms and tumor-host interactions underlying metastasis formation requires realistic animal models for de novo spontaneous tumor development and metastasis. This session will bring together experts who are focusing on metastasis in genetically engineered mouse models representing major human malignancies. Their presentations will focus on metastasis propagating cells, cancer cell dissemination, and the role of host factors in metastasis.

    186

    AACR 102nd Annual Meeting 2011 April 26, 2011

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