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Anne Bülow- Combinatorial Synthesis of Cocaine Analogues

Anne Bülow- Combinatorial Synthesis of Cocaine Analogues

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Published by: GummyCola on Jan 09, 2012
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11/16/2012

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Combinatorial Synthesis of Cocaine Analogues
and
Competition Reactions between Glucosyl Donors andGalactosyl Donors - A Study of Glycosidation Reactions
and
Determination of Thermodynamic Parameters for Binding of Azasugars to Almond
β
-GlucosidasePh.D.dissertation submitted by:Anne BülowDepartment of ChemistryUniversity of AarhusAugust 2004
 
 
 
 iii
i
 
Table of Contents
i Table of Contents...........................................................................................................iiiii Preface............................................................................................................................viiiii Acknowledgements......................................................................................................viiiiv List of Appendices..........................................................................................................ixv List of Abbreviations.......................................................................................................xvi Summary........................................................................................................................xii 
Chapter I: Combinatorial Synthesis of Cocaine Analogues
1 INTRODUCTION...........................................................................................................1
1.1 C
OCAINE
 – 
A
S
TIMULANT OF THE
C
ENTRAL
 N
ERVOUS
S
YSTEM
.............................11.2 D
EVELOPMENT OF
M
EDICATIONS FOR 
T
REATMENT OF
C
OCAINE
A
BUSE
...............31.3 P
OTENTIAL
D
OPAMINE
T
RANSPORTER 
L
IGANDS
....................................................41.3.1 Phenyltropanes..........................................................................................41.3.2
 
Various Structural Classes of Potential Dopamine Transporter Ligands10
 
1.4 P
URPOSE OF THIS
W
ORK 
.......................................................................................12
2 COMBINATORIAL CHEMISTRY............................................................................14
2.1 I
 NTRODUCTION
.....................................................................................................142.2 I
DENTIFICATION OF
A
CTIVE
C
OMPOUNDS IN A
L
IBRARY
......................................152.3 S
OLID
P
HASE VERSUS
S
OLUTION
P
HASE
A
PPROACHES
.........................................17
3 THE GRIGNARD REACTION...................................................................................19
3.1 T
HE
G
RIGNARD
EAGENT
....................................................................................193.1.1
 
Grignard Reagents in Conjugate Addition..............................................20
 
3.2 T
HE
G
RIGNARD
EACTION IN
C
OMBINATORIAL
C
HEMISTRY
...............................21
4 SYNTHESIS OF THE TROPANE SKELETON.......................................................22
4.1 S
YNTHESES OF
C
OCAINE AND OTHER 
T
ROPANES
..................................................22

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