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Invitro Dissolution And Assay of "Ibuprofen"Tablet.

Invitro Dissolution And Assay of "Ibuprofen"Tablet.



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Published by Md.Moniruzzaman
This is project work when I completed my B.Pharm (Hons).I try my best to give every information about Ibuprofen tablet. In my project work I perform with 5 different companies Ibuprofen tablet.
This is project work when I completed my B.Pharm (Hons).I try my best to give every information about Ibuprofen tablet. In my project work I perform with 5 different companies Ibuprofen tablet.

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Published by: Md.Moniruzzaman on Nov 07, 2008
Copyright:Attribution Non-commercial


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1.1 Introduction :
Ibuprofen (from the now outdated nomenclature iso-butyl-propanoic-phenolic acid) is a non-steroidal anti-inflammatory drug (NSAID). It is a colorlesscrystalline solid widely used as an analgesic and anti-inflammatory medication. It ismost commonly known as ibuprofen, but is also known as α-methyl-4-(2-
methylpropyl) benzeneacetic acid and 4-isobutyl-@alpha;-methylphenylacetic acid.Originally marketed asNurofen,AdvilandMotrinand since then under various other trademarks, most notably Flamex, Profen, Inflam and Reumafen. It is also used forrelief of symptoms of arthritis, primary dysmenorrhea, fever, and as an especiallywhere there is an inflammatory component. Ibuprofen is known to have anantiplatelet effect, though it is relatively mild and short-lived when compared to thatof aspirin or other more well-known antiplatelet drugs. Ibuprofen is a core medicinein the World Health Organization's "Essential Drugs List", which is a list of minimummedical needs for a basic health care system.
2-(4-isobutylphenyl)propionic Acid
Figure: Structure of 
Ibuprofen is a relatively safe drug. Because of its effectiveness and lack of sideeffects, these are now frequently prescribed by the Doctors.
1.2. According to Conventional drug:
Ibuprofen is a widely used non-steroidal anti-inflammatory drug(NSAID). It is also a conventional drug. So ibuprofen is used in conventionaltreatment or therapy.
1.2.1.Conventional treatment:
A currently accepted and widely used treatment for a certain type of disease, based on the results of past research. Also called conventional treatment.
1.2.2. Conventional medicine:
A system in which medical doctors and other healthcare professionals(such as nurses, pharmacists, and therapists) treat symptoms and diseases usingdrugs, radiation, or surgery. Also called Western medicine, mainstream medicine,orthodox medicine, biomedicine, and allopathic medicine.
1.2.3. Conventional drug Therapy 
The short duration of activity is due to the inability of conventionaldosage forms to control temporal delivery. If any attempt is made to maintain drugblood levels in the therapeutic range for longer periods by, for example increasingthe initial dose of an intravenous injection, as shown by the dotted line in the figure,toxic level may be produce at early times. This approach is to administer the drugrepetitively with a constant-dosing interval as in multiple dose therapy, which isshown below in figure for oral route;In this case the drug blood level reached and the time required toreach that level depend on the dose and the dosing interval. There are severalpotential problems inherent in multiple dose therapy.a)If the dosing interval is not appropriate for the biological half-life of the druglarge “peak” and “valley” in the drug blood level may result, e.g. drugs withshort half-lives require frequent dosing to maintain constant therapeuticlevels.b)The drug blood level may not be within the therapeutic range at sufficientlyearly times an important consideration for certain disease states.c)Patients’ noncompliance with multiple dosing regimens can result in failure of this approach.In many instance, potential problem associated with conventionaldrug therapy can be overcome. When this is the case, drugs given in conventionaldosage forms by multiple dosing can produce the desired drug blood level forextended period of time. Frequently however these problems are significant enoughto make drug therapy with conventional dosage forms less desirable than sustaineddrug therapy
1.2.4. Conventional NSAIDs:
It is extremely important to obtain an accurate diagnosis before tryingto find a cure. Many diseases and conditions share common symptoms: if you treatyourself for the wrong illness or a specific symptom of a complex disease, you may

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