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Pharmacology

Pharmacology

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Published by Rushik Dhaduk

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Published by: Rushik Dhaduk on Jan 12, 2012
Copyright:Attribution Non-commercial

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01/10/2014

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Major
TopicAbbreviation
Major
TopicAbbreviationAdrenergicAdrenergicCholinergicCholinergic
AnestheticsAnesthetics
CorticosteroidsCorticosteroids
Arti-Anxlety
Agents
Anti-Anxiety
Agents
CardioysscularCardiovascularAntl-EpilepticsAnti-EpilepticsCancer/Chemotherapy
Cancer/ChemoAnti-DepressantsAnti-Depressants
Dilretics
Diuretics
Anti-Histamires
Anti-HistaminesH!?oglycemics
Hypoglycemics
Anti-lnfectives
Anti-InfectivesMiscellareous
Misc,
Anti-PsychoticsAnti-PsychoticsNarcotic
Analgesics
Narcotic
Analgesics
Aspirin/Acetamitrophen/NSAIDs
Asp/Acet/NSAIDS
Terms/DefinitioDsTerms/Def
PHARMACOLOGY
Adrenergic
Amphetamines
are
sympathomimetic
amines
that
cause
rapid
release
of:
.
Dopamine
in
the
brain
.
Serotonin
in
the
brain
.
Norepinephrinein
the
brain
.
Acetylcholine in
the
brain
1
Copyright
e
2011':0ll
-
Denbl
Decks
 
Amphetamines
pass
readily into
theCNS and
cause a
rapid
release
of
norepinephrine
in
the
brain. Amphetamines increase
systolic
and
diastolic blood
pressuresand act
as
weakbronchodilators
and
respiratory
stimulants. They have
a
high potential
for
abuse,
result-
ing in tolerance,
psychological
dependence, and severe
social
disability.
Abuse
causes
ex-
treme violence
and
paranoid
psychoticbehavior Note:
Amphetamines
and
ephedrine
are
indirectly
acting sympathomimetic(sympathetic-type)
drugs.These
drugs
demonstratetoleranceand
are
orally
active,
unlike
epinephrine
and
norepinephrine.Therapeutic
uses
of
amphetamines:
.
Attention Deficit
Hl?eractivity
Disorder(ADHD;
hyperkinesis)
dextroamphet-amine
(Dexedrine)
and
a
mix of
dextroamphetamine
with
amphetamine
(Adderall);(Adderall
XR)
sometimes
used
instead
ofmethylphenidate
(Ritalin)..
Narcolepsy
-
dextroamphetamine
(Dexedrine)
is used
toprevent
daltime
sleepiness
in
these
patients.
.Weight
loss
-
phentermine
(Ionamin)
-
structurally similar
to dextroamphetamine.1.
Tyrosine hydroxylase
catalyzes the
rate
limiting
step
in
the
synthesis
of
norepinephrine(tr'E)
and
epinephrine. The
enzyme
is
inhibited
by
metyro-
sine.
2.
Terrninationoftransrnission
by NE
takes
place
primarily
by the reuptake
ofNE
intoprejunctional
nerves and
secondarily into
other cells.
Monoamine
oxidase
(MAO)
and
catechol-O-methyl
transferase
(COMT)
then
play
a
role
in
metabolizing
the
NE.
 
.An
alpha-adrenergicreceptor
blocker(alpha-blocker).A
beta-adrenergicreceptor
blocker
@eta-blocker)
Coplright
O
20ll-201?
Dmral
Decks
.
Sympathomimetic
.
Sympatholytic
.
Sympatheticamine
.
Adrenergic
agent
CoplyighrC
201l-2012
DentalDecks

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