Eight patients were studied using implanted microdialysis probes to inject potassium, calcium and glutamate and analyze the effects on extracellular GABA levels.
Likewise, amygdala\u00adkindled rats (an animal\u00admodel of human epilepsy) were similarly studied; additionally, in the rat experiments injections of the specific GABA\u00ad transporter inhibitor nipecotic acid were also assessed both in terms of effects on GABA levels as well as in quantitating the numbers of GABA transporters.
relative increase in K+ stimulated, local, vesicular GABA release but showed
in glutamate stimulated, generalized, transport\u00admediated GABA release.
Technically speaking, microdialysis technically only
extracellular GABA and may not be representative of
In addition, the GABA\u00adtransporter inhibitor nipecotic acid abolished the glutamate\u00admediated increase in extracellular GABA arguing that GABA transport is involved in generalized GABA release.
Scatchard analysis shows an unchanged Kd but a decreased Bmax in amygdala kindled rats arguing for a quantitative reduction (non\u00ad competitive inhibition model) in the number GABA transporters in \u201cepileptic\u201d rats.
This action might not be possible to undo. Are you sure you want to continue?