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Antihistamines

Antihistamines

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Published by Kishore Chandki
Antihistamines in Children: Presentation for Pediatricians & Pediatric Students!
Antihistamines in Children: Presentation for Pediatricians & Pediatric Students!

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Categories:Types, Research
Published by: Kishore Chandki on Feb 08, 2012
Copyright:Attribution Non-commercial

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06/13/2014

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IntroductionIntroduction
AmongstAmongstmost frequently prescribedmost frequently prescribed
More than 40 drugs available worldwideMore than 40 drugs available worldwide
AboutAbout20 drugs20 drugsare available in Indiaare available in India
AAbroad class of pharmacologic agentsbroad class of pharmacologic agentsthat include thethat include the 1st generation, 2nd generation, & now 3rd Gen agents1st generation, 2nd generation, & now 3rd Gen agentsthat inhibit the actions of histamine on H1 receptorsthat inhibit the actions of histamine on H1 receptors
Not receptor antagonists but are µNot receptor antagonists but are µinverse agonistsinverse agonists¶ i.e.¶ i.e. they produce the opposite effect on the receptor tothey produce the opposite effect on the receptor tohistaminehistamine
11
stst
Gen antihistamines never adequately studied for Gen antihistamines never adequately studied for pediatric age groups: still used widelypediatric age groups: still used widely
 
Alle
rgic Cascad
eAlle
rgic Cascad
e
B
cell
B
cell
11
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Allergen exposureAllergen exposureCytokinesCytokinesILIL--4, IL4, IL--1313 SecondSecondAllergenAllergenexposureexposureIgEIgEproductionproductionIgEIgEattachmentattachmentto mast cellto mast cell
allergenallergenspecificspecificmast cellmast cellAllergen attachment &Allergen attachment &degranulation of mast celldegranulation of mast cell

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