AmongstAmongstmost frequently prescribedmost frequently prescribed
More than 40 drugs available worldwideMore than 40 drugs available worldwide
AboutAbout20 drugs20 drugsare available in Indiaare available in India
AAbroad class of pharmacologic agentsbroad class of pharmacologic agentsthat include thethat include the
1st generation, 2nd generation, & now 3rd Gen agents1st generation, 2nd generation, & now 3rd Gen agentsthat inhibit the actions of histamine on H1 receptorsthat inhibit the actions of histamine on H1 receptors
Not receptor antagonists but are µNot receptor antagonists but are µinverse agonistsinverse agonists¶ i.e.¶ i.e.
they produce the opposite effect on the receptor tothey produce the opposite effect on the receptor tohistaminehistamine
Gen antihistamines never adequately studied for Gen antihistamines never adequately studied for pediatric age groups: still used widelypediatric age groups: still used widely