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Induction and Morphogenesis

Induction and Morphogenesis

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Published by: Savannah Simone Petrachenko on Feb 08, 2012
Copyright:Attribution Non-commercial

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08/22/2014

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Induction and Morphogenesis
Readings
y
 
C
hapter 15 ± Section 15.1
y
 
C
hapter 43 ± Section 43.3
y
 
C
hapter 19 ± P.437-439
I
ntroduction
y
 
C
ells in the organizer express and secrete proteins that influencethe behaviour (cell movement) and identities (commitment) of nearby cells
y
 
Induction
is a mechanism for influencing the behaviour and/oridentity of nearby cells.
y
 
A
protein(s) is translated and secreted by some cells to inducenearby cells to change
S
ignals can be both
paracrine
and
autocrine
 Not all cells can respond to a particular signal. A cell must be
competent 
to respond.
 
G
eneral features of signal transduction pathways
O
utside Cell
L
igand (proteins, smallmolecules)
Cytoplasm
Receptor(proteins)Transducer(s)+ Second Messengers(enzymes)(small molecules)
Nucleus
Effector(transcription factors)Target(genes)
T
wo Modes of 
I
nductive
S
ignaling
A relay mechanism induces multiple cell fates by using multiple signals
 
 
Morphogens are special signaling proteins that are involved in patterning embryos viagradient signaling
y
 
Properties of morphogens«
o
 
Induce different cell fates at different concentrations
o
 
C
an act at a distance
o
 
H
ave a
direct
effect on the target cellDifferent cellular response at different morphogen concentrations
A morphogen acts directly on a distant target cell

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