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Twenty-One_Nobel Prize Expts

Twenty-One_Nobel Prize Expts

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Published by sharebee

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Published by: sharebee on Nov 19, 2008
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05/09/2014

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How Scientists Think:
Twenty-One Experiments that Have Shaped Our Understanding ofGenetics and Molecular Biologyby George Johnson
This concise book is an intriguing way to foster critical thinking and reinforce the scientific method inyour biology course. It expands on the experiments offered in Biology, with 21 chapters devoted todiscussions ofclassic genetics or molecular biology experiments-many on which the study of biology isfounded. Package this book with Biology for a discounted price."This short companion is intended to ... provide students with a closer look at some key experiments, as away of learning how a proper experiment is put together, of seeing how a control works, of appreciatingthe raw originality that sometimes adds flavor and excitement to science-and, above all, of seeing howscience is really done. Clean, clear thinking lies at the heart of every good experiment.I have increasingly come to believe that Charles Yanofsky had it right-that the best way to understandscience in general is to study science in particular. Exposed to one experimental problem in detail, thestudent learns far more than just the details of the particular experiment. Said simply, the student learnshow the experimenter thinks. Learning how a successful experiment was put together teaches the logic of scientific inquiry, the very heart of the science."...from the Preface of How Scientists Think, by George B. Johnson
Contents
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Preface
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1. ANFINSEN - Amino Acid Sequence Determines Protein Shape
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Anfinsen's Experiment
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Unfolding Ribonuclease
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Refolding Ribonuclease
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Why Ribonuclease Refolded the Way It Did
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2. MORGAN - Genes Are Located on Chromosomes
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Variation in Independent Assortment
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Enter Drosophila melanogaster
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Morgan's Historic Fruit Fly Crosses
 
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X and Y Chromosomes
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Sex Linkage
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3. MORGAN - Genes on the Same Chromosome Do Not Assort Independently
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Deviations from Mendel's Predicted Ratios
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Testing de Vries's Hypothosis
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Coupling vs. Repulsion
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Linkage Reflects Physical Association of Genes
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4. STURTEVANT - The First Genetic Map: Drosophila X Chromosome
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Linked Genes May Be Mapped by Three-Factor Test Crosses
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Sturtevant's Experiment
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Analyzing Sturtevant's Results
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Interference
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The Three-Point Test Cross in Corn
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5. McCLINTOCK/STERN - Genetic Recombination Involves Physical Exchange
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The Mechanics of Recombination
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McClintock's Zea mays
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Stern's Drosophila melanogaster
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6. GRIFFITH/HERSHEY/CHASE - DNA Is the Genetic Material
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Identification of DNA
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DNA and Heredity
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DNA Can Genetically Transform Cells
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Griffith's Experiment
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Hershey and Chase's Experiment
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The Tobacco Mosaic Virus (TMV)
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7. MESELSON/STAHL - DNA Replication Is Semiconservative
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Semiconservative Replication
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Conservative Replication
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Semiconservative or Conservative
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Meselson and Stahl's Experiment
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8. CHAMBON - Discovery of Introns
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When Is a Deletion Not Really a Deletion?
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Chambon's Experiment
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9. KORNBERG - Isolating DNA Polymerase
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The Polymerization of DNA
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Kornberg's Methods
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Kornberg's Results
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DNA Polymerase
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Poly-II and Poly-III
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10. OKAZAKI - DNA Synthesis Is Discontinuous
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The Puzzle in the DNA Synthesis Model
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Okazaki's Research
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11. JACOB/MESELSON/BRENNER - Discovery of Messenger RNA (mRNA)
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How Is Information in DNA Expressed?

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