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Orally Based Diagnosis of Celiac Disease

Orally Based Diagnosis of Celiac Disease

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Published by Nidhin Valappila
oral medicine celiac disease
oral medicine celiac disease

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Categories:Types, Research
Published by: Nidhin Valappila on Feb 12, 2012
Copyright:Attribution Non-commercial

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10/26/2014

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INTRODUCTION
´
Celiac disease (Non tropical sprue, glutensenseitive enteropathy, Gee-Herter disease) is aunique autoimmune disorder, unique because theenvironmental precipitant is known.
´
The disorder was previously called celiac sprue,based on the Dutch word
sprue,
which was usedto describe a disease similar to tropical sprue thatis characterized by diarrhea, emaciation,aphthous stomatitis, and malabsorption.
 
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Celiac disease is precipitated, in geneticallypredisposed persons, by the ingestion of gluten,the major storage protein of wheat and similargrains. Originally considered a rare malabsorptionsyndrome of childhood, celiac disease is nowrecognized as a common condition that may bediagnosed at any age and that affects manyorgan systems.
 
PA
THOGENESIS
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Celiac disease results from the interaction between glutenand immune, genetic, and environmental factors.
The Role of Gluten
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Celiac disease is induced by the ingestion of gluten, whichis derived from wheat, barley, and rye. It is comprised of hundreds of protein components, traditionally classified onthe basis of their solubility in alcohol-water solutions, inprolamins (alcohol-soluble), and glutenins (alcoholinsoluble) (Wieser, 2007).

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