Stage of Alzheimer’s DiseaseTests/CriteriaClinical or Research Use
Notable dierences rom 1984NINCDS-ADRDA criteria includeormulation o 3 AD stages andinclusion o biomarkers.Broad consensus that use o biomarkersmust be validated and standardizedbeore routine clinical application.
1. Probable AD dementia (coreclinical criteria) – includes meetingthe clinical criteria or all-causedementia along with insidiousonset; clear history o worsening o cognition by report or observation;and initial and most prominentcognitive defcits include amnesticpresentation and/or defcits inlanguage presentation, visuospatialpresentation and executiveunction.2. Possible AD dementia –diagnosis or patients who meetcore clinical criteria but exhibit anatypical course o cognitive declineor mixed etiological presentation.3. Probable AD dementia withevidence o AD pathophysiology – diagnosis or patients whomeet the core clinical criteriaand incorporate biomarkers,advanced imaging and evaluation o biochemical changes.1. Probable AD dementia criteriaretained the ramework o the 1984NINCDS-ADRDA criteria and can beused in the clinical setting.2. Possible AD dementia criteria can beused in the clinical setting. Any patientwith previous possible AD dementiaper the 1984 NINCDS-ADRDA criteriashould be reevaluated with the updatedcriteria.3. It is not recommended to usebiomarker tests or routine AD diagnosis.I undertaken, biomarker evidence may increase the certainty that clinically assessed dementia is due to the ADpathological process.
April 2011 alz.org
for healthcare professionals
New Diagnostic Criteria and Guidelines for Alzheimer’s Disease
Expert workgroups spearheaded by the Alzheimer’s Association and the National Institute on Aging o the NationalInstitutes o Health have developed new criteria and guidelines or the diagnosis o Alzheimer’s disease which are nowavailable online through the
Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association.
Go toalz.org/detectionDXor more inormation.The new criteria and guidelines include recommendations or clinical oce settings and research settings as illustrated bythe ollowing Summary Table.
Criteria and Guidelines for Alzheimer’s Disease
Clinical UseResearch Use
D e m e n t i a d u e t o A D I n t r o