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Inbrief Links 42011

Inbrief Links 42011

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Published by: Pri-Med on Feb 21, 2012
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05/24/2012

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Stage of Alzheimers DiseaseTests/CriteriaClinical or Research Us
Notable dierences rom 1984NINCDS-ADRDA criteria includeormulation o 3 AD stages andinclusion o biomarkers.Broad consensus that use o biomarkersmust be validated and standardizedbeore routine clinical application.
Dementia due to Alzheimer’sDisease(McKhann et al, 2011)Includes 3 sets of criteria:1. Probable AD dementia2. Possible AD dementia3. Probable AD dementiawith evidence of ADpathophysiology
1. Probable AD dementia (coreclinical criteria) – includes meetingthe clinical criteria or all-causedementia along with insidiousonset; clear history o worsening o cognition by report or observation;and initial and most prominentcognitive defcits include amnesticpresentation and/or defcits inlanguage presentation, visuospatialpresentation and executiveunction.2. Possible AD dementia –diagnosis or patients who meetcore clinical criteria but exhibit anatypical course o cognitive declineor mixed etiological presentation.3. Probable AD dementia withevidence o AD pathophysiology – diagnosis or patients whomeet the core clinical criteriaand incorporate biomarkers,advanced imaging and evaluation o biochemical changes.1. Probable AD dementia criteriaretained the ramework o the 1984NINCDS-ADRDA criteria and can beused in the clinical setting.2. Possible AD dementia criteria can beused in the clinical setting. Any patientwith previous possible AD dementiaper the 1984 NINCDS-ADRDA criteriashould be reevaluated with the updatedcriteria.3. It is not recommended to usebiomarker tests or routine AD diagnosis.I undertaken, biomarker evidence may increase the certainty that clinically assessed dementia is due to the ADpathological process.
April 2011 alz.org
in brief 
 
 for healthcare professionals
New Diagnostic Criteria and Guidelines for Alzheimer’s Disease
Expert workgroups spearheaded by the Alzheimer’s Association and the National Institute on Aging o the NationalInstitutes o Health have developed new criteria and guidelines or the diagnosis o Alzheimer’s disease which are nowavailable online through the
 Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association.
Go toalz.org/detectionDXor more inormation.The new criteria and guidelines include recommendations or clinical oce settings and research settings as illustrated bythe ollowing Summary Table.
Summary Table.
Criteria and Guidelines for Alzheimer’s Disease 
Clinical UseResearch Use
  D  e  m  e  n  t  i  a   d  u  e  t  o  A  D  I  n  t  r  o

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