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Alcohols

Alcohols

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Published by dhainey
if you drink dont drive =)
if you drink dont drive =)

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Published by: dhainey on Nov 23, 2008
Copyright:Attribution Non-commercial

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09/07/2012

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ETHANOL
n
Chemistry
¡
Ethyl alcohol
¡
Water-soluble aliphatic alcohol
¡
Product of fermentation of sugars
n
Pharmacokinetics
¡
Absorbed in the stomach and small intestine
¡
Highly lipid soluble widely distributed in thebody
¡
1
st
pass hepatic metabolism
¡
Biotransformation primarily (90%) in the liver:
n
Alcohol dehydrogenase pathway
n
Hepatic microsomal ethanol oxidizing system (MEOS)
n
Catalase system
 
 
ETHANOL METABOLISM:
AlcoholDehydrogenase Pathway
Stage 1CH
3
-CH
2
OH + NAD
+
Alcohol dehydrogenaseCH
3
-CHO (Acetaldehyde) + NADH + H
-
Stage 2CH
3
CHO + H
2
OAldehyde dehydrogenaseCH
3
-COOH (Acetate) + (2H)Stage 3CH
3
-COOH + 4(O) 2CO
2
+ 2H
2
O
 
ETHANOL METABOLISM:
MEOS & Catalase System
EthanolMEOS / Catalase(NADPH / O
2
)AcetaldehydeAldehyde dehydrogenaseAcetate

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