VITAMIN B12 PRODUCTION
AIM & OBJECTIVE:
Vitamin B12 Production
Vitamin B-12 is normally involved in the metabolism of every cell of the body,especially affecting the DNA synthesis, normal functioning of brain and nervous system,and formation of blood and regulation but also fatty acid synthesis and energy production. However, many (though not all) of the effects of functions of B-12 can bereplaced by sufficient quantities of
, since B-12 is used to regenerate folatein
the body. Most "B-12 deficient symptoms" are actually folate deficient symptoms, sincethey include all the effects of
and megaloblastosis, which are due to
poor synthesis of DNA when the body does not have a proper supply of
A transdermal vitamin B12 delivery patch is applied to the skinof a user for the delivery of vitamin B12 to the bloodstream of the user. The patchincludes a fabric backing and a skin-adhesive polymer matrix that is attached to one sideof the fabric backing. The matrix contains a vitamin B12 compound. The vitamin B12compound diffuses from the matrix through the stratum corneum layer of the user's skin,through the dermis layer of the skin, and into the user's bloodstream.
On the applicationof serum vitamin B12 radio-assay is used to the diagnosis of cobalt deficiency insheep.
Vitamin B-12 cannot be made by plants or animals as only bacteriahave the enzymesrequired for its synthesis. Vitamin B-12 deficiency can potentially cause severe andirreversible damage, especially to the brain and nervous system. At levels only slightlylower than normal, a range of symptoms such asfatigue,depression,and poor memory
may be experienced. So vitamin b12 is produced by the process of fermentation in bacteria as well as industrially. it is produced by methanol utilizing bacteria, use of cheese whey , production by citrobacter ferenduii by tempeh fermentation, lactobacillusreuteri, efficient production by propionic acid bacteria under periodic variation of dissolved oxygen concentration, production in fermented milk products continuousmethane fermentation and production of vitamin b12 in fixed bed reactors packed withloopah. All these processes of fermentations in bacteria are used for the production of vitamin b12.
is the name for a class of chemically-related compounds, all of whichhave vitamin activity. It is structurally the most complicated vitamin.Biosynthesisof