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Addisons (C)

Addisons (C)

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Published by Cymon Jimenez

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Published by: Cymon Jimenez on Mar 25, 2012
Copyright:Attribution Non-commercial

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10/25/2013

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ADRENAL CORTEXZONA FASCICULATA
 GLUCOCORTICOIDCortisol(SUGAR
)
 Affects:
-
CHO, CHON, fat metabolism
-
After stress rx
-
Inhibition of inflammatoryresponse
-
Controls glucosemetabolismZONA GLOMERULOSA
 MINERALCORTICOIDAldosterone(SALT)Fx: promotes Na & H2Oreabsorption & excretion ofpotassium (SALT)Regulate Na & electrolyte imbalanceZONA RETICULARIS
 ANDROGEN(SEX)M
 –
testosteroneF
 –
estrogen & progesteroneFx
 –
promotes development ofsecondary sexual characteristicsa.) Metabolic disturbances (sugar)b.) F&E imbalances- Na, H2O, Kc.) Deficiency of neuromuscular function (salt & sex)
Addison’s Disease
 
 Predisposing Factors:1. Atrophy of adrenal gland2. Fungal infections3. Tubercular infections
-
 
GlucocorticoidDecrease sugarMineralocorticoidDecrease saltAndrogenDecrease Sex1)
↓ gluconeogenesis (hypoG)
 
 T
 –
tremors, tachycardiaI - irritabilityR - restlessnessE
 –
extreme fatigueD
 –
diaphoresis, depression2) Decrease plasma cortisol
 
Decrease tolerance/ resistance tostress3) Pathognomonic sign:Normally cortisol nnhibitsmelanocyte stimulating hormonedue to decrease cortisol willstimulate pituitary gland to releasemelanocyte stimulating hormone.
 HyperpigmentationBronze like skin pigmentation(Meticulous skin care)
↑ sodium excretion
 Hyponatermia
 Hypovolemiaa.) Hypotensionb.)
↓ CO
 c.) Signs of dehydration
 –
 extreme thirst, agitationd.) Wt lossHyperkalemiaa.) Irritabilityb.) Diarrheac.) ArrhythmiaClinical Manifestations:(MAD-HEG)M-uscle weakness and fatigue
from KretentionA-norexiaD-ark pigmentationH-ypotensionE-maciationG-I sxLess axillary and pubic hairDecrease sexual urge or libido-Decreased AndrogenLoss of pubic and axillary hair
↓ blood glucose
 
↓Sodium
 
↑Potassium
 

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