Pathogenesis, diagnosis and treatment of Rasmussen encephalitis A European consensus statement
University of Bonn, Department of Epileptology, Bonn,Germany,
Instituto Nazionale Neurologico ‘C. Besta’, Milan, Italy,
Institute of Child Health and Great Ormond Street Hospital for ChildrenNHS Trust, London, UK,
Service de Maladies Métaboliques et Neurologie Hôpital Necker Enfant Malades, Paris, France,
Medical University of Vienna, Brain Research Institute, Vienna, Austria, and
Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
Correspondence to: Dr Christian G. Bien, University of Bonn,Department of Epileptology, Sigmund-Freud-Str. 25, 53105 Bonn, Germany E-mail:email@example.com
Received September 21, 2004.
Revision received January 6, 2005.
Rasmussen encephalitis (RE) is a rare but severe immune-mediated brain disorderleading to unilateral hemispheric atrophy, associated progressive neurologicaldysfunction and intractable seizures. Recent data on the pathogenesis of the disease,its clinical and paraclinical presentation, and therapeutic approaches aresummarized. Based on these data, we propose formal diagnostic criteria and atherapeutic pathway for the management of RE patients.