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Dr Raghuveer Choudhary
When no chyme is in the small intestine, the hepatopancreatic sphincter is closed. Bile flows into gallbladder.
cystic duct
common hepatic duct common bile duct
pancreas
Function of Gallbladder - absorbs water and stores the bile for later use.
Gallbladder
Sac-like organ attached to the inferior surface of the liver. Stores and concentrates bile. When gallbladder fills with bile, it expands.
Contraction of the muscularis layer of the gallbladder, ejects bile into the common bile duct into duodenum.
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Bile Release
Bile
- is constantly produced by the liver (500-1,000 mL of bile per day). - is a yellow-green fluid containing : minerals bile pigments bile acids phospholipids cholesterol neutral fats facilitate fat digestion and absorption
Composition of bile
Bile is an alkaline solution containing a number of components. The important ones for digestion are bile salts, cholesterol and phospholipids. Bile salts act as a fat emulsifier they break globules of fat entering the small intestine into millions of fatty droplets. This provides a large surface area for the fat digesting enzymes to work on.
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Composition of Bile
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(continued)
Biliary Secretion A. Bile is secreted continuously by the liver, and the rate of secretion depends on whether a fed or fasting state exists. B. Bile contains bile salts, lecithin (a phospholipid), cholesterol, bile pigments (eg, bilirubin), water, and electrolytes. C. Bile constituents are dissolved in an alkaline solution resembling pancreatic juice. Bile plays an important role in the intestinal digestion and absorption of lipids. D. Primary bile acidscholic acid and chenodeoxycholic acidare synthesized by the liver from cholesterol. The lipid-soluble bile acids are conjugated with either glycine or taurine.
Because they are ionized at neutral pH, conjugated bile acids exist as salts of sodium or potassium and, therefore, are known as bile salts.
F. Secondary bile acids are formed by deconjugation and dehydroxylation of the primary bile salts by intestinal bacteria, forming deoxycholic acid from cholic acid and lithocholic acid from chenodeoxycholic acid.
G. Lithocholic acid is hepatotoxic and is normally excreted in feces. H. The bile acid pool, which under normal conditions is constant in size (about 24 g), is a mass of primary and secondary bile acids.
1)
Fats are first broken up into smaller emulsification droplets by lecithin and bile salts (acids) in the bile.
2) When lipase digests fats, the products are two fatty acids (FFAs) and a monoglyceride.
3) Bile salts coat these and other lipids and form droplets called micelles.
Micelles release their lipids, which diffuse freely across the plasma membrane.
Chylomicrons are too large to enter blood capillaries and must be first transported in the lymphatic lacteal.
Bile salts
Fat globule
emulsification droplets
chylomicrons micelles
Intestinal lumen
lacteal
blood
Effects of Cholecystectomy The periodic discharge of bile from the gallbladder aids digestion but is not essential for it. Cholecystectomized patients maintain good health and nutrition with a constant slow discharge of bile into the duodenum, although eventually the bile duct becomes somewhat dilated, and more bile tends to enter the duodenum after meals than at other times. Cholecystectomized patients can even tolerate fried foods, although they generally must avoid foods that are particularly high in fat content.