An antigen is a substance either protein or non- protein, whichif introduced into and individual causes the production of an
In the practice of blood transfusion , red cell antigens are ofmajor clinical importance, though platelets, leucocytes and
plasma proteins exhibit strong antigenic systems
The Four blood groups are determined by the presence orabsence of blood group Antigens ( agglutinogens) on the red
cell and so individual’s group is A,B, AB or O.