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Autoimmunity

Autoimmunity

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Published by gechdk20002836
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Published by: gechdk20002836 on May 17, 2012
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08/04/2012

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Autoimmunity
1/19/2010Adane M (AAU, FoM, DMIP)
 
Autoimmunity results from a failure or breakdown of themechanisms normally responsible for maintaining self-tolerance in B cells, T cells, or both
Failure of T cell tolerance is an important mechanism of autoimmune diseases.-The lesions are caused by cell-mediated immunereactions-Helper T cell abnormalities may also lead toautoantibody production
1/19/2010Adane M (AAU, FoM, DMIP)
 
The major factors that contribute to the developmentof autoimmunity are genetic susceptibility andenvironmental triggers, such as infections
Autoimmune diseases may be either systemic ororgan specific-the formation of circulating immune complexescomposed of self antigens and specific antibodies typicallyproduces systemic diseases, such as SLE. In contrast,autoantibody or T cell responses against self antigens withrestricted tissue distribution lead to organ-specific diseases,such as myasthenia gravis, T10, and MS
1/19/2010Adane M (AAU, FoM, DMIP)

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