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Table Of Contents

Leptin Signal Transduction— A 2009 Update
Leptin and the Leptin Receptor
JAK Kinase
Activation of STAT3
Activation of the ERK Pathway
Perspective
Tree Binding Sites in Leptin
Models of the CRH2-Leptin Complex
Models for the Ig-Like and CRH1 Domains
Homology Model for a Hexameric 2:4 Leptin:LR Complex
Homology Models for the Fibronectin Type III Domains
Mechanism of LR Activation
Development of Leptin-Based Antagonists
Optimization of Leptin-Based Antagonists
Concluding Remarks
Activation Mechanism of OB-R Studied with Biochemical Methods
Methodological Introduction to FRET/BRET
Activation Mechanism of OB-R Monitored by FRET and BRET
Is Leptin a Pro- or Anti-Apoptotic Agent?
Apoptosis: A Basic Biologic Phenomenon
Anti-Apoptotic Efects of Leptin
Pro-Apoptotic Efects of Leptin
Leptin Actions in the Gastrointestinal Tract
Gastric Leptin Directly Activates Vagal Aferent Neurons
Leptin and Intestinal Physiology
Leptin in Gastrointestinal Pathologies
Conclusions and Perspectives
Leptin as a Novel Marker in Breast and Colorectal Cancer
Leptin and Breast Cancer
Leptin and Colorectal Cancer
Summary and Perspectives
Te Role of Leptin in Cardiac Physiology and Pathophysiology
Leptin Synthesis and Structure
Leptin Resistance
Expression of Leptin Receptors in Cardiovascular Tissues
Efect of Leptin on Cardiomyocyte Function
Cardiomyocyte Hypertrophic Efects of Leptin
Leptin as a Cardioprotective Agent
Post Receptor Leptin Signaling
Conclusions: Potential of Leptin Modulators as Terapeutic Agents
Te Role of Leptin in Bone Development and Growth
Te Efect of Leptin on the Skeleton
Leptin and Growth
Central Efect of Leptin
Peripheral/Direct Efect of Leptin
Synopsis
Involvement of Leptin in Arterial Hypertension
Physiological Efects of Leptin Relevant for Blood Pressure Regulation
Selective and Peripheral Leptin Resistance
Prohypertensive Efects of Chronic Hyperleptinemia
Conclusions and Future Perspectives
Overview of the Leptin System
Leptin System in the Endometrium
Leptin System in the Implantation Process
Leptin System in the Endometriosis
Summary and Conclusions
Te Use of Leptin for the Treatment of Lipodystrophy
Metabolic Efects of Leptin Terapy
Endocrine Efects of Leptin Terapy
Hepatic and Muscular Efects of Leptin Terapy
Conclusion
Leptin Has Multiple Functions in Immunity
Leptin Is Involved in the Development of Various Diseases
Leptin-Receptor Neutralization
Results
Chronic Hepatitis and Fibrosis
Conclusions
Background
Leptin and Developmental Programming
Evidence from Animal Models
Epidemiological and Clinical Evidence
Leptin in Early Life and Catch-Up Growth
Potential Mechanisms
Discussion
Index
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LEPTIN_05941587063204

LEPTIN_05941587063204

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Published by: DEEPSKYWALKER on May 17, 2012
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