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DOD Letter to National Toxicity Panel on TCE

DOD Letter to National Toxicity Panel on TCE

Ratings: (0)|Views: 2,138 |Likes:
Dec-01-00 14:36

a

2

2

1999

P.02

DEPARTMENT OF THE AIR FORCE
AIR FORCE INSTITUTE FOR ENVIRONMENT, SAFETY AND OCCUPATIONAL HEALTH RISK ANALYSIS (AFMC) BROOKS AIR FORCE BASE TEXAS

1 December 2000

MEMORANDUM I-OR OR. MARY S. WOLFE P.O. BOX 12233, A3-07 RESEARCH TRIANGLE PARK NC 27709 ATTENTION: EXECUTIVE SECRETARY FROM: AFIERA/RSRE 2513 Kennedy Circle Brooks AFB TX 78235-5123 SU BJECT: NTP Board of Scientific Counselors RoC Subcommittee Meeting, 13 • 15 Dec 00 I. In reference to the Federal
Dec-01-00 14:36

a

2

2

1999

P.02

DEPARTMENT OF THE AIR FORCE
AIR FORCE INSTITUTE FOR ENVIRONMENT, SAFETY AND OCCUPATIONAL HEALTH RISK ANALYSIS (AFMC) BROOKS AIR FORCE BASE TEXAS

1 December 2000

MEMORANDUM I-OR OR. MARY S. WOLFE P.O. BOX 12233, A3-07 RESEARCH TRIANGLE PARK NC 27709 ATTENTION: EXECUTIVE SECRETARY FROM: AFIERA/RSRE 2513 Kennedy Circle Brooks AFB TX 78235-5123 SU BJECT: NTP Board of Scientific Counselors RoC Subcommittee Meeting, 13 • 15 Dec 00 I. In reference to the Federal

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Categories:Types, Letters
Published by: Children Of Vietnam Veterans Health Alliance on May 21, 2012
Copyright:Attribution Non-commercial

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Dec 01 00
14:36
a
22
1999
P 02
DEPARTMENT
OFTHE
AIR
FORCE
AIR
FORCE
INSTITUTE
FOR
ENVIRONMENT,
SAFETYAND
OCCUPATIONAL
HEALTHRISK
ANALYSIS
 AFMC BROOKS
AIR
FORCE
BASETEXAS
1December2000
MEMORANDUM
I OROR
MARY
S.
WOLFEP.O.
BOX
12233,
A3-07
RESEARCH
TRIANGLE
PARKNC
27709ATTENTION:
EXECUTIVE
SECRETARY
FROM:
AFIERA/RSRE2513KennedyCircleBrooks
AFB
TX
78235-5123
SU
BJECT:
NTP
Board
of
ScientificCounselors
RoC
SubcommitteeMeeting,
13
15
Dec
00
I.
In
reference
to
theFederalRegisterNotice October17,2000,
Vol65
Number
210:
65352-61354 ,the
U.S.
AirForcewould
like
tosubmitwritten
comments
regardingtheproposedchange
in
cancerclassificationfortrichloroethylenerecommended
by
the
NationalToxicology
Program
 NTP
seeAttachment .
In
addition,the
U.S.
Air
Force
requeststime
to
speak
on
thistopic
at
the
up
coming
NTPBoardofScientificCounselors
RoC
Subcommittee,to
take
place
13
-
 
December,2000.
The
U.S.
Air
Forceoral
comments
will
coverandpossiblyexpand
on
key
issuesdiscussed
in
thesubmittedwrittencomments.
2.
Contactinformation
for
oml
comments
is
asfollows:
Elizabeth
A.
Maull.
Ph.D.
AFInstituteForEnvironment.SafetyandOccupational
Health
Risk
Analysis AFIERA
2513
KennedyCircleBrooksAirForce
Base
TX
78235·5123 210 536-6126 210 536-1130elizabeth.maull@brooks.af.mil
3.
J
will
 
your
point
of
contact
for
b h
the
written
and
oralcommentsforthe
U.S.
Air
Force.
Pleaseaddressanyquestionsorconcerns
to
me
at
 210 536-6126ore-mailelizabeth.maull@brooks.af.mil.Theattachedwrittencommentshavealso
been
postedthroughtheregular
mail.
ttt JA
A
 /. d~
ELIZABETH
A.
MAULL.
Ph.
D.
ToxicologistAttachment:SAF/MIO
Memo.
29Nov
00,
w/l
atch
cc:
SAF/MIQ
 
22
 
~
DEPARTMENTOFTHE
AIR
FORCE
WASHINGTON
OQ
P 03
 
. -J~
... Ii-
Ofta
Of
The
AIIai lantSecretary
.
MEMORANDUM
FOR
OR.MARYS.
WOLFE
P.
O.
:JO)f-:n2 33-;
1t3 ~-
RE~-H f1iU1:\1 lG~KNC2n09
 ~
xecutiV
SECKETARY
FROM:SAFfMIQ
1660
Air
ForcePentagon
WashingronDC20030-1660
SUBJEct :
Comment )
for
the
National
ToxicologyProgram
Regarding
the
Upgrade
ofTrichloroethylene
TheDepartmemofDefenliewould
Iik.e
to
thank.
the
National
Toxicology
Program
(NTP)
for
me
opportUnity
to
commentoa.Ibeir
curumI
~menda1ion
10
reclassify.tricblomelb)l1cne
 TeE)
to
 known
to
be
(ll)
bum
an
c8l£ill&pa..
TridU<>rQ4tfilylene
is
a
chemical
that
has
balL
widespread
use
throughol1c
the
000
,in.ce
t~
earlYifA
o t i~
century.
As
a
resulr,
spent
tCE
wasdisposed
of
in
accorcbmce
with
the-be5tprilcricn-ofttJe
day,
althoughsome
refeoasf.
ofTCE-
wasunintentional.TheDoDaclcnowtedpsresponribilityforsuch
envirofl'l1tf:Tlt:l1
releases,includin,lheneedton:,ducc:any
asSOtiutcctrtsk5
~o
reasonablelevels.
Based
on
thefollowing
criteria
for
the known
ro
be
Human
Carcinogen :
 There
is
sufficient
evidence
of
carcinogenicity
from
stuwes
in
humans.
which
indicates
a
causal
relationship
} erwee.a.elCpclQMr
to.ebe.
 in
su.biunce.Qt.mixrore
uQ.tllm.aD.
caecv
We
do
notbelievetherequirementfor
causality
between.exposures
to
Te
and
human
cancers
has
been
met
Our
specifi(;
WililliCU1S1UC
pto't ided
in
the
attachment.
·Tbe
Bepaniiitilt
of
DeftMe
rec UIlReUds
thar
lite
cancer
ctIIssifiCaftCIJ
teillmn
3S'
reportedin
tfre
~
edition
of me
ReportonCarcilIt1lcns,
 reasonably
anticipated
lObe-(a)lluman
cDtCinogen.
M
There
are
widevariations
in
cpidemiolo~al
srudr
retults,
likely
due
to
 be
inahility
to.
separate
the
healtheffectsof
TeE
from
tbose
associatedwith
other
solvCl1ts.
In
thosestudies
with
positivefindings,
the
sue.ocr
b
of.uSl¥ iarjon
i\modcsc
at
bur
Trichlomemy1elVl
has.beeg
re-evaJuaced
by
both
the
Inte~iMal
Aacac¥
lor
iM lila on
Cancer
(lARC.
1
~.an4W:
American
Conferen<:e
OfGo
....
:::LW
 
ln.lI.iall Nc:iat
(ACeIH.
1993):Meid'Jer
cPthe eo
-
groups
found
thatthere
w~
sufficieclt
 1f'o
..
l ion
 
to
'ClassifY
Te
as
a
Imown
Ilamasl
carcinogen.
In
fact,
ACOrn
ct lsli:ied~1s
A,5--l1ON'tlspec:ted'as
ahumancarcinogen
based
on
pro~rfy
conducted
epic:hmUologic
ltudi-es
in
humans.
 
22
1999
P 4
4 '-''-'
......
 
_i oi
t.J.:...~
 
2
Torank
a
chemical
as
a
knownhuman
cl1rcinopn
is
obviouslyamajordecision
with
wide~
reac:hin;impact;onceso
rOlnkcd.
it
willbt
extremely
difficulttoccturn
to
it
lowerclassification
rank.
Consequently,
it
 
very
impommt
 CtTittth;s
bell
welt-informeddecision
based
«1
a
preponderance
of
sc;jentificdata.Withoutan) cItilt-cutevidence
thuc
TeE
is
c u s ily
ASsociated
w;th
cancer(s)
in
a
significant
manner,
the
Oepanmenl
of
Defense
takes
exception
to
the
National
ToxicologyProgram s
(NTP)
proposal
to
elevatetrichloroethylene
to
thestatus
of
 known
to
be
human
carcinogen.
Outpoint
of
contactisDr.ElizabethMaull.AFIERAJRSRE.(210).536·6126ore-mail
elizabeth·mayU@braoks·ai.mil;
 
w
MCCAI
 
.JR..
 
ANi .nt
SCCfelaq
.«
.-Air-fi1orce
~1.ii hmel1f.
Safety,
amt
· Occu~ationar eaIth
)Attachment:
T~hnic-aJ
COiiiiuents
cc:
DUSD Est
DASA:SOH)
DASN(E S)
 

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