An immune responsemobilizes a batteryof effector moleculesthat act to removeantigen by variousmechanisms
Generally, theseeffector moleculesinduce a localizedinflammatoryresponse thateliminates antigenwithout extensively
damaging the host’s
tissue.Under certaincircumstanceshowever, thisinflammatoryresponse can havedeleterious effects,resulting insignificant tissuedamage or evendeath
This inappropriateimmune responseis termed
Portier and Richet coined the term anaphylaxis.
loosely translated from Greek to mean the opposite of prophylaxis, to describe this overreaction.
Richet was subsequently awarded the Nobel Prize in Physiologyor Medicine in 1913 for his work on anaphylaxis.