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Safety Issues in Magnetic Resonance Imaging

Safety Issues in Magnetic Resonance Imaging

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Published by gasfgd
Magnevist crosses the placenta and appears within the fetal bladder soon after intravenous administration. It
is excreted into the amniotic fluid, only to be swallowed and go through the same cycle. However, the absorption of
any form of gadolinium from the gastrointestinal tract is less than 1.0% (53). Studies have shown that contrast
media can cause adverse effects on the fetus of animal models, however. Magnevist has been shown experimentally
to cause fetal developmental delay without congenital anomalies when given in 2.5 times the human dose to rats
and in 7.5 times the human dose to rabbits (37). ProHance can have adverse effects on the animal fetus at 5 times the
human dose. Furthermore, fetal loss is enhanced with increasing doses of ProHance. There are no studies of the
safety of MRI contrast agents in pregnant women. The recommendations, therefore, are to defer contrast agents in pregnant patients unless the benefits clearly outweigh the risks (37,38).

It is amazing how they thought this product was safe.
Magnevist crosses the placenta and appears within the fetal bladder soon after intravenous administration. It
is excreted into the amniotic fluid, only to be swallowed and go through the same cycle. However, the absorption of
any form of gadolinium from the gastrointestinal tract is less than 1.0% (53). Studies have shown that contrast
media can cause adverse effects on the fetus of animal models, however. Magnevist has been shown experimentally
to cause fetal developmental delay without congenital anomalies when given in 2.5 times the human dose to rats
and in 7.5 times the human dose to rabbits (37). ProHance can have adverse effects on the animal fetus at 5 times the
human dose. Furthermore, fetal loss is enhanced with increasing doses of ProHance. There are no studies of the
safety of MRI contrast agents in pregnant women. The recommendations, therefore, are to defer contrast agents in pregnant patients unless the benefits clearly outweigh the risks (37,38).

It is amazing how they thought this product was safe.

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Published by: gasfgd on Jun 04, 2012
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11/07/2012

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