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Conjugate s

Conjugate s

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Published by Pratyush Sharma

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Published by: Pratyush Sharma on Jun 22, 2012
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06/22/2012

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Antibody-metal ionconjugates
 
Deferoxamine
DFA or deferoxamine is a naturally occurringproduct is isolated from Streptomyces pilosus.Its native activity is forming iron complexesThe amine group of DFA can be utilized for directlabeling of antibodies and other proteins throughcoupling with available carboxylates usingcarbodiimide-mediated conjugation with EDC
 
It has medical applications as a chelatingagent used to remove excess iron from thebody.The mesylate salt of DFO-B is commerciallyavailableIt can also bind to aluminium or othetrivalent atoms.

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