Disease Pathognomonic sign

Duchenne's Muscular Dystrophy Gowers' sign

Hypocalcemia Trousseau sign and Chvostek sign
Tetanus Risus sardonicus
Liver cirrhosis Spider angioma
Systemic Lupus Erythematosus Butterfly rash
Chipmunk facies (parotid gland swelling) (Chipmunk facies also
Bulimia Nervosa
seen in marrow expansion secondary to Beta Thalassemia Major)
Leprosy Leonine facies (thickened lion-like facial skin)
Measles Koplik's spots
Diphtheria Pseudomembrane on tonsils, pharynx and nasal cavity
Grave's disease New bilateral Exophthalmos
Pancreatitis Cullen's sign (bluish discoloration of umbilicus)
Chronic hemorrhagic pancreatitis Grey-Turner's sign (ecchymosis in flank area)
Cholera Rice-watery stool
Typhoid fever Rose spots in abdomen
Meningitis Kernig's sign and Brudzinski's sign
Murphy's sign (pain on deep inspiration when inflamed
Cholecystitis
gallbladder is palpated)
Angina pectoris Levine's sign (hand clutching of chest)
Patent ductus arteriosus Machine-like murmur
Parkinson’s disease Pill-rolling tremors
Whipple's disease Oculo-Masticatory Myorhythmia
Rib fracture Pain produced with attempts to sleep on one's back
Acute Myeloid Leukemia Auer rod
Multiple Sclerosis Bilateral internuclear ophthalmoplegia
Third heart sound Congestive heart failure
Pericardial friction rub Pericarditis