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Among the signs that, in all diseases, the state of mind and thewhole demeanour of the patient are the most certain andinstructive. In the case of ever so slight an improvement weobserve a greater degree of comfort, increased calmness andfreedom of the mind, higher spirits -a kind of return of thenatural state. In the case of ever so small a commencement ofaggravation we have, on the contrary, the exact opposite ofthis: a constrained helpless, pitiable state of the disposition, ofthe mind, of the whole demeanour, and of all gestures,postures and actions, which may be easily perceived on closeobservation, but cannot be described in words. Aphorism 253,Organon of Medicine.