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Nutrition PDF

Nutrition PDF

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Published by: Susan on Jun 30, 2012
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06/30/2012

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1
Nutrition-Metabolism
Unit 3
© Jim Swan
These slides are from class presentations, reformatted forstatic viewing. The content contained in these pages is alsoin the Class Notes pages in a narrative format. Best screenresolution for viewing is 1024 x 768. To change resolutionclick on start, then control panel, then display, then settings.If you are viewing this in Adobe Reader version 7 and areconnected to the internet you will also be able to access the“enriched” links to notes and comments, as well as webpages including animations and videos. You will also be ableto make your own notes and comments on the pages.Download the free reader from Adobe.com
Real Media filefor entire PDF
 
2
Functions of the Liver
Manufacture -•blood proteins -albumin, clotting proteins•urea -nitrogenous waste from amino acid metabolism•bile -excretory for the bile pigments, emulsification of fats by bile saltsStorage -•glycogen -carbohydrate fuel•iron -as hemosiderin and ferritin•fat soluble vitamins A, D, E, KDetoxification -•alcohol•drugs and medicines•environmental toxins
Two additionalfunctions, proteinmetabolism andglycemicregulation will beconsideredshortly.
 
Two additionalfunctions, proteinmetabolism andglycemicregulation will beconsideredshortly.
 
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The Liver
Portal triad:Portal arterioleportal venulebile ductuleSinusoidsCentral vein of lobuleLeads to hepaticveinKupffer cellsHepatocytes
Sinusoids areformed offenestratedendothelium.
 
Sinusoids areformed offenestratedendothelium.Hepatocytesperform all thefunctions of theliver, dividing upthe taskaccording todemands.
 
Hepatocytesperform all thefunctions of theliver, dividing upthe taskaccording todemands.
From hepaticarteryFrom hepaticportal veinTo bile duct
Structure of the liver -The liver is composed mostly of cells known ashepatocyteswhich perform the functions listed above. They have the abilityto shift functions so their efforts can be directed at what is most needed.They can also divide to repair and replace tissue. Cirrhosis is a conditionwhich can occur in the liver and other organs in which the cellsare damagedas a result of toxins, pathogenic organisms, etc. Cirrhosis causes thickeningand fibrosis and can progressively damage the liver to the pointit can nolonger recover by replacing its cells. Other functions also suffer as morehepatocytesbecome committed to detoxification.The liver is organized into lobes and lobules. Each lobule is served by abranch from the portal vein, the hepatic artery and a bile duct.Blood fromthe artery and vein mixes in sinusoids passing through the lobule.Hepatocytesline the sinusoids and withdraw digestive endproducts, toxins,etc. from the blood. Into the blood the put urea, glucose, and othersubstances. Into the bile ductulethey put bile to be taken to the gallbladderand common bile duct. Kupffercells are found inside the sinusoids tophagocytizedebris, rbc, and pathogens.

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