Dynamics and Complexity of FitzHugh-Nagumo Neuronal Systems
Mada Sanjaya W. S
, Muhammad Yusuf
, Agus Kartono
Theoretical Physics Division, Department of Physics, Faculty of Mathematical and NaturalSciences, Institut Pertanian Bogor, Bogor 16680, Indonesia.
Applied Physics Division, Department of Physics, Faculty of Mathematical and NaturalSciences, Institut Pertanian Bogor, Bogor 16680, Indonesia.
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System of signals propagation from one neuron to another represent event of verycomplex electrochemical mechanism This work adresses the dynamics andcomplexity of neuron mathematical models. The aim is first the understanding of thebiological meaning of existing mathematical systems concerning neurons such asHodgkin-Huxley or FitzHugh-Nagumo models. The local stability and the numericalasymptotic analysis of FitzHugh-Nagumo model are then developed in order tocomprehend the dynamic evolution of a single FitzHugh-Nagumo neuron. Thisexamination naturally comes to the study of neuron networks. The analysis of thesenetworks uses the synchronization theory via connections between neurons and cangive rise to emergent properties and self-organization. Our result leads to a classicallaw which describes many self-organized complex systems like earthquakes,linguistic or urban systems. This has been performed using numerical tools.
: Hodgkin-Huxley models, FitzHugh-Nagumo, action potentials,synchronization, chaos.
Understanding the mechanisms of thepropagation of the nerve activity is one of the fundamental problems in biophysics.The first detailed quantitativemeasurements of the ionic currents wereperformed by Hodgkin and Huxley in theearly 50-s (Hodgkin & Huxley, 1952).Using the voltage clamp technique, theywere able to measure the kinetics of Na+and K+ currents in the squid giant axon.This led them to a set of differentialequations which describe the dynamics of the action potential. Furthermore, bycombining these equations with the cableequation for spreading of current in theaxon they were able to calculate the shapeand velocity of the propagating actionpotentials (Hodgkin & Huxley, 1952). Thepredictions of their model turned out to bein a remarkably good agreement with theexperimental observations.Hodgkin-Huxley model for the actionpotential of a space clamped squid axon isde_ned by the four dimensional vectorfield. with variables (
) thatrepresent membrane potential, activationof a sodium current, activation of apotassium current, and inactivation of thesodium current and a parameter I thatrepresents injected current into the space-clamped axon. Although there areimproved models the Hodgkin-Huxleymodel remains the paradigm forconductance-based models of neuralsystem. FitzHugh was the firstinvestigator to apply qualitative phase-plane methods to understanding theHodgkin-Huxley model. To make