Welcome to Scribd. Sign in or start your free trial to enjoy unlimited e-books, audiobooks & documents.Find out more
Download
Standard view
Full view
of .
Look up keyword
Like this
1Activity
0 of .
Results for:
No results containing your search query
P. 1
mamatAMS37-40-2012

mamatAMS37-40-2012

Ratings: (0)|Views: 5|Likes:
Published by Mada Sanjaya Ws

More info:

Published by: Mada Sanjaya Ws on Jul 06, 2012
Copyright:Attribution Non-commercial

Availability:

Read on Scribd mobile: iPhone, iPad and Android.
download as PDF, TXT or read online from Scribd
See more
See less

07/11/2014

pdf

text

original

 
Applied Mathematical Sciences, Vol. 6, 2012, no. 38, 1863 - 1876
Numerical Simulation Bidirectional ChaoticSynchronization FitzHugh-NagumoNeuronal System
Mustafa Mamat
1,3
, Zabidin Salleh
1
, Mada Sanjaya WS
1,2
and Ismail Mohd
1
 
1
Department of Mathematics, Faculty of Science and Technology, UniversitiMalaysia Terengganu, Kuala Terengganu 21030, Malaysia
 2
Department of Physics, Faculty of Science and Technology, Universitas Islam Negeri Sunan Gunung Djati, Bandung, Indonesia
3
Institute of Oceanography and Environment, Universiti Malaysia Terengganu,Kuala Terengganu 21030, Malaysiamus@umt.edu.my
Abstract
System of signals propagation from one neuron to other represent event of verycomplex electrochemical mechanism. In this work, we studied the dynamics of modified FitzHugh-Nagumo multi neuron model with sinusoidal externalstimulation. In this paper, the coupled model is established on the basis of spikingneuron model, and then the relation of bidirectional coupling strength of the gap junction and the synchronization is discussed in detail. The sufficient condition of complete synchronization is obtained from rigorous mathematical derivation. It isfound that the variation in coupling strength between the neurons leads todifferent types of bifurcations and the system exhibits the existence of fixed point, periodic and spiking chaotic attractor.
Keywords
: action potentials, chaotic synchronization, FitzHugh-Nagumo spikingneuron model.
1 Introduction
Understanding the mechanisms of the propagation of the nerve activity is one of 
 
1864
 M. Mamat, Z. Salleh, M. Sanjaya WS and I. Mohd 
the fundamental problems in biophysics. The first detailed quantitativemeasurements of the ionic currents were performed by Hodgkin and Huxley [1].By using the voltage clamp technique, they were able to measure the kinetics of  Na
+
and K 
+
currents in the squid giant axon. This led them to a set of differentialequations which describe the dynamical of the action potential. Furthermore, bycombining these equations with the cable equation for spreading of current in theaxon, they are able to calculate the shape and velocity of the propagating action potentials [1]. The predictions of their model turned out to be in a remarkablygood agreement with the experimental observations.Hodgkin-Huxley model for the action potential of a space clamped squid axonis defined by four dimensional vector field with variables
v
,
m
,
n
, and
h
which
 
represent membrane potential, activation of a sodium current, activation of a potassium current, and inactivation of the sodium current respectively, and a parameter 
 I 
that represents injected current into the space-clamped axon.Although there are several improved models, the Hodgkin-Huxley model remainsthe paradigm for conductance-based models of neural system. FitzHugh was thefirst investigator who applied the qualitative phase-plane methods to understandthe Hodgkin-Huxley model. To make headway in gaining analytical insight,FitzHugh first considered the variables that change most rapidly, and viewing allothers as slowly varying parameters of the system. By this way, he derived areduced two-dimensional system that could be viewed as a phase plane. From theHodgkin-Huxley equations, FitzHugh noticed that the variables
v
and
m
changemore rapidly than
h
and
n
, at least during certain time intervals. By arbitrarilysetting
h
and
n
to be constant, we can isolate a set of two equations whichdescribe a two-dimensional (
v
,
m
) phase plane [2, 3]. The elegance of applying phase plane methods and reduced systems of equations into this rather complicated problem should not be underestimated.Determining the dynamical behavior of an ensemble of coupled neurons is animportant problem in computational neuroscience where it is commonly usedmodel for the study of individual neuron which displays spiking behavior [1-3].From the very beginning of the research in the field of computationalneuroscience, people deal with single neuron and its behavior. Presently trends of research include the investigation of the behavior of neurons considered in anetwork and their way to fire synchronously. It is assumed that the activities in the brain are synchronous and underlying interests for synchronization of nonlinear oscillators in physical and biological systems range from novel communicationstrategies to understand how large and small neural assemblies efficiently andsensitively achieve desired functional goal. In recent years, there has beentremendous interest for the study of the synchronization of chaotic systems. The phenomenon of synchronism gives rise to different dynamical behaviors such aschaotic synchronization etc [4-8]. The synchronization of chaotic bursting neuronmodels have been studied in detail [9, 10]. In this paper, we studied in detail themodified spiking multi neuron models with external periodic forcing.In this paper, nonlinear dynamical analysis on single and coupled modifiedFitzHugh-Nagumo chaotic spiking model under steady and sinusoidal externalelectrical stimulation are investigated. The effects of parameter variation on its
 
 Numerical simulation
1865
 behavior are discussed first
 
and the effect of coupling strength on dynamics of coupled neurons is studied next. Numerical results in support of our findings arealso presented. Finally, we conclude our work.
2 Mathematical Model of Single Neuron
In this section, we will describe several mathematical models of neuron. We firststudy an original Hodgkin-Huxley single neuron model under external electricalstimulation. After describing the periodic Hodgkin-Huxley model in respond tosteady electric stimulation, we investigate the dynamical behavior of FitzHugh- Nagumo single neuron model under steady external electrical stimulation. Themodified FitzHugh-Nagumo single and couple neuron models under sinusoidalexternal electrical stimulation are studied in the next section.
Basics Models of Neuron
To describe the evolution of the membrane potential
v
in the squid giant axon,Hodgkin and Huxley have developed the following conductance-based model [1,11].
[ ]
===+++=
hvhv dt dhmvmv dt dmnvnv dt dn I vvgvvvngvvhmvg dt dv
hhmmnnext  L L Na Na m
)()1)(( )()1)(( )()1)(( )())(()()( 1
43
 β α  β α  β α 
(1)where
v
=
v
intra
v
extra
represents membrane potential in mV, and
v
intra
,
v
extra
theintracellular and extracellular membrane potential, respectively. The time
ismeasured in msec, the variables
m
,
h
and
n
represent the sodium activation, thesodium inactivation and the potassium activation, respectively. Parameters
v
 Na
,
v
 and
v
l
represent the equilibrium potentials of sodium, potassium and leak current,respectively. They are determined uniquely by the Nernst’s equations.
g
 Na
;
g
and
g
l
are the maximal conductance of the corresponding ionic currents. They reflectthe ionic channel density distributed over the membrane.
m
is the membranecapacitance,
 I 
ext 
is the externally-applied current.
α 
y
(
v
) and
 β 
y
(
v
) (
 y
=
m,h,n
) arenonlinear functions of 
v
, given by the following equations:
1
))10/)40(exp(1)(40(1.0)(
++=
vvv
m
α 
,
)18/)65(exp(4)(
+=
vv
m
 β 
 )20/)65(exp(07.0)(
+=
vv
h
α 
,
1
))10/)35(exp(1()(
++=
vv
h
 β 
 

You're Reading a Free Preview

Download
scribd
/*********** DO NOT ALTER ANYTHING BELOW THIS LINE ! ************/ var s_code=s.t();if(s_code)document.write(s_code)//-->